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The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549652/ https://www.ncbi.nlm.nih.gov/pubmed/29781368 http://dx.doi.org/10.1080/21541248.2018.1463895 |
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author | Villagomez, Fabian R. Medina-Contreras, Oscar Cerna-Cortes, Jorge Francisco Patino-Lopez, Genaro |
author_facet | Villagomez, Fabian R. Medina-Contreras, Oscar Cerna-Cortes, Jorge Francisco Patino-Lopez, Genaro |
author_sort | Villagomez, Fabian R. |
collection | PubMed |
description | The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia. |
format | Online Article Text |
id | pubmed-7549652 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-75496522020-10-27 The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia Villagomez, Fabian R. Medina-Contreras, Oscar Cerna-Cortes, Jorge Francisco Patino-Lopez, Genaro Small GTPases Review The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia. Taylor & Francis 2018-05-28 /pmc/articles/PMC7549652/ /pubmed/29781368 http://dx.doi.org/10.1080/21541248.2018.1463895 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Review Villagomez, Fabian R. Medina-Contreras, Oscar Cerna-Cortes, Jorge Francisco Patino-Lopez, Genaro The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
title | The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
title_full | The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
title_fullStr | The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
title_full_unstemmed | The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
title_short | The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
title_sort | role of the oncogenic rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549652/ https://www.ncbi.nlm.nih.gov/pubmed/29781368 http://dx.doi.org/10.1080/21541248.2018.1463895 |
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