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The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role...

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Autores principales: Villagomez, Fabian R., Medina-Contreras, Oscar, Cerna-Cortes, Jorge Francisco, Patino-Lopez, Genaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549652/
https://www.ncbi.nlm.nih.gov/pubmed/29781368
http://dx.doi.org/10.1080/21541248.2018.1463895
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author Villagomez, Fabian R.
Medina-Contreras, Oscar
Cerna-Cortes, Jorge Francisco
Patino-Lopez, Genaro
author_facet Villagomez, Fabian R.
Medina-Contreras, Oscar
Cerna-Cortes, Jorge Francisco
Patino-Lopez, Genaro
author_sort Villagomez, Fabian R.
collection PubMed
description The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia.
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spelling pubmed-75496522020-10-27 The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia Villagomez, Fabian R. Medina-Contreras, Oscar Cerna-Cortes, Jorge Francisco Patino-Lopez, Genaro Small GTPases Review The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia. Taylor & Francis 2018-05-28 /pmc/articles/PMC7549652/ /pubmed/29781368 http://dx.doi.org/10.1080/21541248.2018.1463895 Text en © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Villagomez, Fabian R.
Medina-Contreras, Oscar
Cerna-Cortes, Jorge Francisco
Patino-Lopez, Genaro
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
title The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
title_full The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
title_fullStr The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
title_full_unstemmed The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
title_short The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
title_sort role of the oncogenic rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549652/
https://www.ncbi.nlm.nih.gov/pubmed/29781368
http://dx.doi.org/10.1080/21541248.2018.1463895
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