Using Optical Quality Analysis System for predicting surgical parameters in age-related cataract patients

The Optical Quality Analysis System (OQAS, Visiometrics) provides objective measurements of image formed onto retina, by combining quantification of ocular media transparency and of optical aberrations. In order to evaluate its contribution in the assessment of age-related cataract, we conducted a monocentric clinical study to determine the relationships between clinical grading of lens opacity, OQAS parameters, and parameters required for cataract surgery by phacoemulsification with ultrasound (called “phacodynamics”). Clinical parameters were: best-corrected visual acuity (BCVA, expressed as Log of minimal angle resolution (logMAR)) and the lens opacity classification system III (LOCS III) as a gold standard determined by two independent observers who graded total cataract and nuclear, cortical and posterior sub capsular components. The OQAS provided an objective scatter index (OSI), a modulation transfer function (MTF, expressed in cycle per degree (cpd)) and a Strehl ratio (SR) used as an aberration marker. Patients were operated on by the same surgeon using a phacoemulsification machine that provided the cumulative dissipated energy (CDE) and total ultrasound time (US time) necessary to extract the lens. Patients with poor compliance, corneal or retinal diseases impairing OSI, or who required surgical settings variation, were excluded. Twenty-one eyes of 21 patients aged 76±8 years were analyzed. They were 11 pure nuclear, 3 pure cortical, and 7 mixed cataracts. Mean LOCS III and OSI were respectively: 4.86 ±2.03 and 6.12 ±3.07 (mean±SD). Medians (10°-90° percentiles) were: for BCVA 0.30 (0.10–0.70) logMAR, for MTF cutoff 9.31 (1.54–30.57) cpd, for SR 0.071 (0.042–0.146), for CDE 8.04 (5.74–23.29) and for US time 58 (39–116) seconds. LOCS III was significantly correlated (spearman r, r(s)) with BCVA (r(s) = 0.561, p = 0.008), CDE (r(s) = 0.457, p = 0.038) and US time (r(s) = 0.647, p = 0.002). The three OQAS parameters significantly correlated (all r(s) ≥ 0.526, p<0.05) with BCVA, and LOCS III grading, but the strongest correlations were found with OSI for cortical components and with MTF for nuclear components: only OSI may be used objectively to assess the effect of cortical components on optical quality, and MTF cutoff—integrating scattering and aberrations—seems the best objective parameter for clinical assessment of nuclear cataracts. The three OQAS parameters were also significantly correlated (r(s)) with CDE, and with US time only for pure nuclear cataracts: OSI had the strongest correlations with phacodynamics (r(s) = 0.693, p = 0.022 with CDE and r(s) = 0.703, p = 0.019 US time). OSI increased with cortical components not requiring higher CDE. When measured in optimal conditions (good compliance, no retinal or ocular surface or tear film diseases), the three OQAS parameters are complementary for objective grading of cataract. In the future, they may help to optimize surgical parameters, especially energy distribution, in femtosecond laser assisted cataract surgery.