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Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature

Temperature influences fish’s susceptibility to infectious disease through an immune response. However, the mechanism underlying this regulation is yet to be elucidated. In this study, we compared the susceptibility of crucian carp that were grown at 18°C and 33°C, respectively, to Aeromonas sobrial...

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Autores principales: Jiang, Ming, Yang, Li-Fen, Zheng, Jun, Chen, Zhuang-Gui, Peng, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549911/
https://www.ncbi.nlm.nih.gov/pubmed/32698656
http://dx.doi.org/10.1080/21505594.2020.1787604
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author Jiang, Ming
Yang, Li-Fen
Zheng, Jun
Chen, Zhuang-Gui
Peng, Bo
author_facet Jiang, Ming
Yang, Li-Fen
Zheng, Jun
Chen, Zhuang-Gui
Peng, Bo
author_sort Jiang, Ming
collection PubMed
description Temperature influences fish’s susceptibility to infectious disease through an immune response. However, the mechanism underlying this regulation is yet to be elucidated. In this study, we compared the susceptibility of crucian carp that were grown at 18°C and 33°C, respectively, to Aeromonas sobrial infection and found that crucian carp was more susceptible when grown at 33°C. These distinct susceptibilities of fish at different temperatures to infection may partially be explained by their differences in the metabolism as revealed by comparative metabolomics profiling: crucian carp demonstrated enhanced TCA cycle but reduced fatty acid biosynthesis; Our study also found that maltose was the most suppressed metabolite in fish grown at 33°C. Importantly, exogenous injection of maltose enhances crucian carp survival grown at 33°C by 30%. Further study showed that exogenous maltose downregulated the production of several cytokines but enhanced the lysozyme (lyz) and complement component c3, which involves the humoral innate immunity. Our results suggest that maltose promotes the survival of crucian carp likely through fine tuning the immune gene expression, and this finding provides a novel approach to manage bacterial infection.
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spelling pubmed-75499112020-10-27 Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature Jiang, Ming Yang, Li-Fen Zheng, Jun Chen, Zhuang-Gui Peng, Bo Virulence Research Paper Temperature influences fish’s susceptibility to infectious disease through an immune response. However, the mechanism underlying this regulation is yet to be elucidated. In this study, we compared the susceptibility of crucian carp that were grown at 18°C and 33°C, respectively, to Aeromonas sobrial infection and found that crucian carp was more susceptible when grown at 33°C. These distinct susceptibilities of fish at different temperatures to infection may partially be explained by their differences in the metabolism as revealed by comparative metabolomics profiling: crucian carp demonstrated enhanced TCA cycle but reduced fatty acid biosynthesis; Our study also found that maltose was the most suppressed metabolite in fish grown at 33°C. Importantly, exogenous injection of maltose enhances crucian carp survival grown at 33°C by 30%. Further study showed that exogenous maltose downregulated the production of several cytokines but enhanced the lysozyme (lyz) and complement component c3, which involves the humoral innate immunity. Our results suggest that maltose promotes the survival of crucian carp likely through fine tuning the immune gene expression, and this finding provides a novel approach to manage bacterial infection. Taylor & Francis 2020-07-22 /pmc/articles/PMC7549911/ /pubmed/32698656 http://dx.doi.org/10.1080/21505594.2020.1787604 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Jiang, Ming
Yang, Li-Fen
Zheng, Jun
Chen, Zhuang-Gui
Peng, Bo
Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_full Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_fullStr Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_full_unstemmed Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_short Maltose promotes crucian carp survival against Aeromonas sobrial infection at high temperature
title_sort maltose promotes crucian carp survival against aeromonas sobrial infection at high temperature
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549911/
https://www.ncbi.nlm.nih.gov/pubmed/32698656
http://dx.doi.org/10.1080/21505594.2020.1787604
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