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Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic

A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania...

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Autores principales: Pițigoi, Daniela, Săndulescu, Oana, Crăciun, Maria Dorina, Drăgănescu, Anca, Jugulete, Gheorghiță, Streinu-Cercel, Anca, Vișan, Angelica, Rîciu, Claudia, Rafila, Alexandru, Aramă, Victoria, Luminos, Monica, Streinu-Cercel, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549973/
https://www.ncbi.nlm.nih.gov/pubmed/32507005
http://dx.doi.org/10.1080/21505594.2020.1771948
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author Pițigoi, Daniela
Săndulescu, Oana
Crăciun, Maria Dorina
Drăgănescu, Anca
Jugulete, Gheorghiță
Streinu-Cercel, Anca
Vișan, Angelica
Rîciu, Claudia
Rafila, Alexandru
Aramă, Victoria
Luminos, Monica
Streinu-Cercel, Adrian
author_facet Pițigoi, Daniela
Săndulescu, Oana
Crăciun, Maria Dorina
Drăgănescu, Anca
Jugulete, Gheorghiță
Streinu-Cercel, Anca
Vișan, Angelica
Rîciu, Claudia
Rafila, Alexandru
Aramă, Victoria
Luminos, Monica
Streinu-Cercel, Adrian
author_sort Pițigoi, Daniela
collection PubMed
description A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania during the first three years of the current measles epidemic (July 2016–July 2019). More than half of the patients (57.6%) had ages below 5 years; 6% (n = 82) had preexisting comorbidities. Only 1.5% of the patients had been fully vaccinated, 5.9% had received only one vaccine dose, while 92.8% had not been vaccinated at all against measles. The rate of measles-related complications was 93.4%; complications occurred more frequently among patients who were not eligible for vaccination due to young age or underlying diseases, and among children, who developed pneumonia and enterocolitis more frequently than adults. The median hospital length-of-stay was 6 days. Eight cases (0.6%) required intensive care and mechanical ventilation, and three deaths (0.2%) were recorded. Measles disproportionately affects patient groups who are not eligible for vaccination. During the current epidemic in Romania, 98.5% of the patients hospitalized for measles had not been vaccinated and among these, 75.7% would have been eligible for vaccination. For the remaining pool of unvaccinated children, supplementary immunization activities are urgently needed.
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spelling pubmed-75499732020-10-22 Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic Pițigoi, Daniela Săndulescu, Oana Crăciun, Maria Dorina Drăgănescu, Anca Jugulete, Gheorghiță Streinu-Cercel, Anca Vișan, Angelica Rîciu, Claudia Rafila, Alexandru Aramă, Victoria Luminos, Monica Streinu-Cercel, Adrian Virulence Research Paper A large measles epidemic has been ongoing in Romania and many European countries, since 2016. We report case-based surveillance data for all patients (n = 1371) with laboratory-confirmed and epidemiologically-confirmed measles hospitalized in a major infectious diseases hospital in Bucharest Romania during the first three years of the current measles epidemic (July 2016–July 2019). More than half of the patients (57.6%) had ages below 5 years; 6% (n = 82) had preexisting comorbidities. Only 1.5% of the patients had been fully vaccinated, 5.9% had received only one vaccine dose, while 92.8% had not been vaccinated at all against measles. The rate of measles-related complications was 93.4%; complications occurred more frequently among patients who were not eligible for vaccination due to young age or underlying diseases, and among children, who developed pneumonia and enterocolitis more frequently than adults. The median hospital length-of-stay was 6 days. Eight cases (0.6%) required intensive care and mechanical ventilation, and three deaths (0.2%) were recorded. Measles disproportionately affects patient groups who are not eligible for vaccination. During the current epidemic in Romania, 98.5% of the patients hospitalized for measles had not been vaccinated and among these, 75.7% would have been eligible for vaccination. For the remaining pool of unvaccinated children, supplementary immunization activities are urgently needed. Taylor & Francis 2020-06-07 /pmc/articles/PMC7549973/ /pubmed/32507005 http://dx.doi.org/10.1080/21505594.2020.1771948 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Pițigoi, Daniela
Săndulescu, Oana
Crăciun, Maria Dorina
Drăgănescu, Anca
Jugulete, Gheorghiță
Streinu-Cercel, Anca
Vișan, Angelica
Rîciu, Claudia
Rafila, Alexandru
Aramă, Victoria
Luminos, Monica
Streinu-Cercel, Adrian
Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_full Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_fullStr Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_full_unstemmed Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_short Measles in Romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
title_sort measles in romania – clinical and epidemiological characteristics of hospitalized measles cases during the first three years of the 2016-ongoing epidemic
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7549973/
https://www.ncbi.nlm.nih.gov/pubmed/32507005
http://dx.doi.org/10.1080/21505594.2020.1771948
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