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Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine

The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small i...

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Autores principales: Gramatiuk, Svetlana Mykolayivna, Bagmut, Irina Yurievna, Ivanova, Julia Viktorivna, Tymchenko, Mykhailo Yevhenovych, Kryvorotko, Igor Vadimovich, Pak, Svetlana Oleksyiyivna, Sheremet, Michael Ivanovich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550135/
https://www.ncbi.nlm.nih.gov/pubmed/33072210
http://dx.doi.org/10.25122/jml-2020-0083
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author Gramatiuk, Svetlana Mykolayivna
Bagmut, Irina Yurievna
Ivanova, Julia Viktorivna
Tymchenko, Mykhailo Yevhenovych
Kryvorotko, Igor Vadimovich
Pak, Svetlana Oleksyiyivna
Sheremet, Michael Ivanovich
author_facet Gramatiuk, Svetlana Mykolayivna
Bagmut, Irina Yurievna
Ivanova, Julia Viktorivna
Tymchenko, Mykhailo Yevhenovych
Kryvorotko, Igor Vadimovich
Pak, Svetlana Oleksyiyivna
Sheremet, Michael Ivanovich
author_sort Gramatiuk, Svetlana Mykolayivna
collection PubMed
description The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small intestine with the formation of intestinal anastomoses at the State Institution “Zaytsev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine”. Of all the operated patients, there were 55.2% women and 44.8% men. Of the 96 patients examined, cryoglobulinemia was detected in the majority – 62.5% of patients, of which 4 were later proved to have inactive hepatitis C; the remaining 38.5% had no cryoglobulinemia. According to the existing theory of the autoimmune mechanism of postoperative surgical complications formation, the revealed decrease in the level of cryoglobulins on the second day could be related to their fixation in the microcirculatory bed and the development of immunocomplex inflammation. While the increase in the content of cryoglobulins in serum on the third day can be caused by their entry into the circulatory bed from deposition or fixation sites and the development of a secondary immune response. In patients with intestinal anastomosis failure after resection of intestinal segments, cryoglobulinemia rates increased more than 80 mg/l; this indicator could be used as a marker of postoperative complications.
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spelling pubmed-75501352020-10-16 Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine Gramatiuk, Svetlana Mykolayivna Bagmut, Irina Yurievna Ivanova, Julia Viktorivna Tymchenko, Mykhailo Yevhenovych Kryvorotko, Igor Vadimovich Pak, Svetlana Oleksyiyivna Sheremet, Michael Ivanovich J Med Life Original Article The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small intestine with the formation of intestinal anastomoses at the State Institution “Zaytsev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine”. Of all the operated patients, there were 55.2% women and 44.8% men. Of the 96 patients examined, cryoglobulinemia was detected in the majority – 62.5% of patients, of which 4 were later proved to have inactive hepatitis C; the remaining 38.5% had no cryoglobulinemia. According to the existing theory of the autoimmune mechanism of postoperative surgical complications formation, the revealed decrease in the level of cryoglobulins on the second day could be related to their fixation in the microcirculatory bed and the development of immunocomplex inflammation. While the increase in the content of cryoglobulins in serum on the third day can be caused by their entry into the circulatory bed from deposition or fixation sites and the development of a secondary immune response. In patients with intestinal anastomosis failure after resection of intestinal segments, cryoglobulinemia rates increased more than 80 mg/l; this indicator could be used as a marker of postoperative complications. Carol Davila University Press 2020 /pmc/articles/PMC7550135/ /pubmed/33072210 http://dx.doi.org/10.25122/jml-2020-0083 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Original Article
Gramatiuk, Svetlana Mykolayivna
Bagmut, Irina Yurievna
Ivanova, Julia Viktorivna
Tymchenko, Mykhailo Yevhenovych
Kryvorotko, Igor Vadimovich
Pak, Svetlana Oleksyiyivna
Sheremet, Michael Ivanovich
Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
title Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
title_full Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
title_fullStr Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
title_full_unstemmed Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
title_short Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
title_sort diagnostic abilities for determining the level of blood cryoglobulins in the choice of tactics for operations on the small intestine
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550135/
https://www.ncbi.nlm.nih.gov/pubmed/33072210
http://dx.doi.org/10.25122/jml-2020-0083
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