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Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine
The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small i...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550135/ https://www.ncbi.nlm.nih.gov/pubmed/33072210 http://dx.doi.org/10.25122/jml-2020-0083 |
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author | Gramatiuk, Svetlana Mykolayivna Bagmut, Irina Yurievna Ivanova, Julia Viktorivna Tymchenko, Mykhailo Yevhenovych Kryvorotko, Igor Vadimovich Pak, Svetlana Oleksyiyivna Sheremet, Michael Ivanovich |
author_facet | Gramatiuk, Svetlana Mykolayivna Bagmut, Irina Yurievna Ivanova, Julia Viktorivna Tymchenko, Mykhailo Yevhenovych Kryvorotko, Igor Vadimovich Pak, Svetlana Oleksyiyivna Sheremet, Michael Ivanovich |
author_sort | Gramatiuk, Svetlana Mykolayivna |
collection | PubMed |
description | The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small intestine with the formation of intestinal anastomoses at the State Institution “Zaytsev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine”. Of all the operated patients, there were 55.2% women and 44.8% men. Of the 96 patients examined, cryoglobulinemia was detected in the majority – 62.5% of patients, of which 4 were later proved to have inactive hepatitis C; the remaining 38.5% had no cryoglobulinemia. According to the existing theory of the autoimmune mechanism of postoperative surgical complications formation, the revealed decrease in the level of cryoglobulins on the second day could be related to their fixation in the microcirculatory bed and the development of immunocomplex inflammation. While the increase in the content of cryoglobulins in serum on the third day can be caused by their entry into the circulatory bed from deposition or fixation sites and the development of a secondary immune response. In patients with intestinal anastomosis failure after resection of intestinal segments, cryoglobulinemia rates increased more than 80 mg/l; this indicator could be used as a marker of postoperative complications. |
format | Online Article Text |
id | pubmed-7550135 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75501352020-10-16 Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine Gramatiuk, Svetlana Mykolayivna Bagmut, Irina Yurievna Ivanova, Julia Viktorivna Tymchenko, Mykhailo Yevhenovych Kryvorotko, Igor Vadimovich Pak, Svetlana Oleksyiyivna Sheremet, Michael Ivanovich J Med Life Original Article The study of the incidence of cryoglobulinemia is relevant in patients with an intestinal anastomotic leak. This study aims to determine a laboratory marker of the risk of small intestine anastomotic leak. The study was based on 96 patients who were subjected to resections of segments of the small intestine with the formation of intestinal anastomoses at the State Institution “Zaytsev V.T. Institute of General and Urgent Surgery of National Academy of Medical Sciences of Ukraine”. Of all the operated patients, there were 55.2% women and 44.8% men. Of the 96 patients examined, cryoglobulinemia was detected in the majority – 62.5% of patients, of which 4 were later proved to have inactive hepatitis C; the remaining 38.5% had no cryoglobulinemia. According to the existing theory of the autoimmune mechanism of postoperative surgical complications formation, the revealed decrease in the level of cryoglobulins on the second day could be related to their fixation in the microcirculatory bed and the development of immunocomplex inflammation. While the increase in the content of cryoglobulins in serum on the third day can be caused by their entry into the circulatory bed from deposition or fixation sites and the development of a secondary immune response. In patients with intestinal anastomosis failure after resection of intestinal segments, cryoglobulinemia rates increased more than 80 mg/l; this indicator could be used as a marker of postoperative complications. Carol Davila University Press 2020 /pmc/articles/PMC7550135/ /pubmed/33072210 http://dx.doi.org/10.25122/jml-2020-0083 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Gramatiuk, Svetlana Mykolayivna Bagmut, Irina Yurievna Ivanova, Julia Viktorivna Tymchenko, Mykhailo Yevhenovych Kryvorotko, Igor Vadimovich Pak, Svetlana Oleksyiyivna Sheremet, Michael Ivanovich Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine |
title | Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine |
title_full | Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine |
title_fullStr | Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine |
title_full_unstemmed | Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine |
title_short | Diagnostic Abilities for Determining the Level of Blood Cryoglobulins in the Choice of Tactics for Operations on the Small Intestine |
title_sort | diagnostic abilities for determining the level of blood cryoglobulins in the choice of tactics for operations on the small intestine |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550135/ https://www.ncbi.nlm.nih.gov/pubmed/33072210 http://dx.doi.org/10.25122/jml-2020-0083 |
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