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Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis
Endometriosis is a chronic benign hormone-dependent condition when the endometrial tissue, identical with the endometrium by its morphological and functional properties, grows outside the borders of the uterine mucous membrane. Recent studies have pointed to the possible role of matrix metalloprotei...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Carol Davila University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550149/ https://www.ncbi.nlm.nih.gov/pubmed/33072202 http://dx.doi.org/10.25122/jml-2020-0117 |
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author | Barbe, Adrian Mykhailovych Berbets, Andrii Mykolaiovych Davydenko, Igor Sviatoslavovych Koval, Halyna Danylivna Yuzko, Viktoriia Oleksandrivna Yuzko, Oleksandr Mykhailovych |
author_facet | Barbe, Adrian Mykhailovych Berbets, Andrii Mykolaiovych Davydenko, Igor Sviatoslavovych Koval, Halyna Danylivna Yuzko, Viktoriia Oleksandrivna Yuzko, Oleksandr Mykhailovych |
author_sort | Barbe, Adrian Mykhailovych |
collection | PubMed |
description | Endometriosis is a chronic benign hormone-dependent condition when the endometrial tissue, identical with the endometrium by its morphological and functional properties, grows outside the borders of the uterine mucous membrane. Recent studies have pointed to the possible role of matrix metalloproteinases (MMPs) in the pathogenesis of endometriosis. We suggested a hypothesis that increased expression of MMPs activity in eutopic and ectopic endometrium of patients with endometriosis might correlate with the presence of endometriotic lesions. The aim of the study was to evaluate the level of MMP-2 and MMP-9 expression in the ectopic endometrium of women with visible endometriotic lesions and eutopic endometrium in patients with no signs of endometriosis. The study was conducted on 43 patients. They were divided into two groups. Group 1 included 31 patients with peritoneal/ovarian endometriosis who had undergone laparoscopy and hysteroscopy. Group 2 consisted of 12 patients with leiomyoma, endometrial polyps or relatively healthy patients who had undergone hysterectomy or polypectomy and endometrial curettage. This study showed statistically higher expression of MMP-2 (1.7783 ± 0.22 immunohistochemistry (IHC) optical density score compared to the control group – 1.41± 0.34, p = 0.0017) and MMP-9 (1.352 ± 0.067 versus 1.85 ± 0.26 in the control group, p = 0.001) in ectopic and eutopic endometrium samples from patients with endometriosis compared to samples taken from patients without endometriosis. A strong correlation between expression of the above-mentioned MMPs (r=0.74 for MMP-2 and r=0.88 for MMP-9) in ectopic and eutopic endometrium might be of promising diagnostic value. |
format | Online Article Text |
id | pubmed-7550149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Carol Davila University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-75501492020-10-16 Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis Barbe, Adrian Mykhailovych Berbets, Andrii Mykolaiovych Davydenko, Igor Sviatoslavovych Koval, Halyna Danylivna Yuzko, Viktoriia Oleksandrivna Yuzko, Oleksandr Mykhailovych J Med Life Original Article Endometriosis is a chronic benign hormone-dependent condition when the endometrial tissue, identical with the endometrium by its morphological and functional properties, grows outside the borders of the uterine mucous membrane. Recent studies have pointed to the possible role of matrix metalloproteinases (MMPs) in the pathogenesis of endometriosis. We suggested a hypothesis that increased expression of MMPs activity in eutopic and ectopic endometrium of patients with endometriosis might correlate with the presence of endometriotic lesions. The aim of the study was to evaluate the level of MMP-2 and MMP-9 expression in the ectopic endometrium of women with visible endometriotic lesions and eutopic endometrium in patients with no signs of endometriosis. The study was conducted on 43 patients. They were divided into two groups. Group 1 included 31 patients with peritoneal/ovarian endometriosis who had undergone laparoscopy and hysteroscopy. Group 2 consisted of 12 patients with leiomyoma, endometrial polyps or relatively healthy patients who had undergone hysterectomy or polypectomy and endometrial curettage. This study showed statistically higher expression of MMP-2 (1.7783 ± 0.22 immunohistochemistry (IHC) optical density score compared to the control group – 1.41± 0.34, p = 0.0017) and MMP-9 (1.352 ± 0.067 versus 1.85 ± 0.26 in the control group, p = 0.001) in ectopic and eutopic endometrium samples from patients with endometriosis compared to samples taken from patients without endometriosis. A strong correlation between expression of the above-mentioned MMPs (r=0.74 for MMP-2 and r=0.88 for MMP-9) in ectopic and eutopic endometrium might be of promising diagnostic value. Carol Davila University Press 2020 /pmc/articles/PMC7550149/ /pubmed/33072202 http://dx.doi.org/10.25122/jml-2020-0117 Text en ©Carol Davila University Press This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Barbe, Adrian Mykhailovych Berbets, Andrii Mykolaiovych Davydenko, Igor Sviatoslavovych Koval, Halyna Danylivna Yuzko, Viktoriia Oleksandrivna Yuzko, Oleksandr Mykhailovych Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis |
title | Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis |
title_full | Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis |
title_fullStr | Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis |
title_full_unstemmed | Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis |
title_short | Expression and Significance of Matrix Metalloproteinase-2 and Matrix Metalloproteinas-9 in Endometriosis |
title_sort | expression and significance of matrix metalloproteinase-2 and matrix metalloproteinas-9 in endometriosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550149/ https://www.ncbi.nlm.nih.gov/pubmed/33072202 http://dx.doi.org/10.25122/jml-2020-0117 |
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