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Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey

Retinal axon projections form a map of the visual environment in the tectum. A zebrafish larva typically detects a prey object in its peripheral visual field. As it turns and swims towards the prey, the stimulus enters the central, binocular area, and seemingly expands in size. By volumetric calcium...

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Autores principales: Förster, Dominique, Helmbrecht, Thomas O, Mearns, Duncan S, Jordan, Linda, Mokayes, Nouwar, Baier, Herwig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550190/
https://www.ncbi.nlm.nih.gov/pubmed/33044168
http://dx.doi.org/10.7554/eLife.58596
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author Förster, Dominique
Helmbrecht, Thomas O
Mearns, Duncan S
Jordan, Linda
Mokayes, Nouwar
Baier, Herwig
author_facet Förster, Dominique
Helmbrecht, Thomas O
Mearns, Duncan S
Jordan, Linda
Mokayes, Nouwar
Baier, Herwig
author_sort Förster, Dominique
collection PubMed
description Retinal axon projections form a map of the visual environment in the tectum. A zebrafish larva typically detects a prey object in its peripheral visual field. As it turns and swims towards the prey, the stimulus enters the central, binocular area, and seemingly expands in size. By volumetric calcium imaging, we show that posterior tectal neurons, which serve to detect prey at a distance, tend to respond to small objects and intrinsically compute their direction of movement. Neurons in anterior tectum, where the prey image is represented shortly before the capture strike, are tuned to larger object sizes and are frequently not direction-selective, indicating that mainly interocular comparisons serve to compute an object’s movement at close range. The tectal feature map originates from a linear combination of diverse, functionally specialized, lamina-specific, and topographically ordered retinal ganglion cell synaptic inputs. We conclude that local cell-type composition and connectivity across the tectum are adapted to the processing of location-dependent, behaviorally relevant object features.
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spelling pubmed-75501902020-10-14 Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey Förster, Dominique Helmbrecht, Thomas O Mearns, Duncan S Jordan, Linda Mokayes, Nouwar Baier, Herwig eLife Neuroscience Retinal axon projections form a map of the visual environment in the tectum. A zebrafish larva typically detects a prey object in its peripheral visual field. As it turns and swims towards the prey, the stimulus enters the central, binocular area, and seemingly expands in size. By volumetric calcium imaging, we show that posterior tectal neurons, which serve to detect prey at a distance, tend to respond to small objects and intrinsically compute their direction of movement. Neurons in anterior tectum, where the prey image is represented shortly before the capture strike, are tuned to larger object sizes and are frequently not direction-selective, indicating that mainly interocular comparisons serve to compute an object’s movement at close range. The tectal feature map originates from a linear combination of diverse, functionally specialized, lamina-specific, and topographically ordered retinal ganglion cell synaptic inputs. We conclude that local cell-type composition and connectivity across the tectum are adapted to the processing of location-dependent, behaviorally relevant object features. eLife Sciences Publications, Ltd 2020-10-12 /pmc/articles/PMC7550190/ /pubmed/33044168 http://dx.doi.org/10.7554/eLife.58596 Text en © 2020, Förster et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Förster, Dominique
Helmbrecht, Thomas O
Mearns, Duncan S
Jordan, Linda
Mokayes, Nouwar
Baier, Herwig
Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
title Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
title_full Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
title_fullStr Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
title_full_unstemmed Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
title_short Retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
title_sort retinotectal circuitry of larval zebrafish is adapted to detection and pursuit of prey
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550190/
https://www.ncbi.nlm.nih.gov/pubmed/33044168
http://dx.doi.org/10.7554/eLife.58596
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