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The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019
BACKGROUNDS: The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients'...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550234/ https://www.ncbi.nlm.nih.gov/pubmed/33045772 http://dx.doi.org/10.3346/jkms.2020.35.e349 |
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author | Kim, In-Cheol Song, Jin Eun Lee, Hee Jung Park, Jeong-Ho Hyun, Miri Lee, Ji Yeon Kim, Hyun Ah Kwon, Yong Shik Park, Jae Seok Youn, Jong-Chan Hwang, Jongmin Lee, Cheol Hyun Cho, Yun-Kyeong Park, Hyoung-Seob Yoon, Hyuck-Jun Nam, Chang-Wook Han, Seongwook Hur, Seung-Ho Eisen, Howard J. Kim, Hyungseop |
author_facet | Kim, In-Cheol Song, Jin Eun Lee, Hee Jung Park, Jeong-Ho Hyun, Miri Lee, Ji Yeon Kim, Hyun Ah Kwon, Yong Shik Park, Jae Seok Youn, Jong-Chan Hwang, Jongmin Lee, Cheol Hyun Cho, Yun-Kyeong Park, Hyoung-Seob Yoon, Hyuck-Jun Nam, Chang-Wook Han, Seongwook Hur, Seung-Ho Eisen, Howard J. Kim, Hyungseop |
author_sort | Kim, In-Cheol |
collection | PubMed |
description | BACKGROUNDS: The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes. METHODS: This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed. RESULTS: A total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P = 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P = 0.008). CONCLUSION: The increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19. |
format | Online Article Text |
id | pubmed-7550234 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-75502342020-10-20 The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 Kim, In-Cheol Song, Jin Eun Lee, Hee Jung Park, Jeong-Ho Hyun, Miri Lee, Ji Yeon Kim, Hyun Ah Kwon, Yong Shik Park, Jae Seok Youn, Jong-Chan Hwang, Jongmin Lee, Cheol Hyun Cho, Yun-Kyeong Park, Hyoung-Seob Yoon, Hyuck-Jun Nam, Chang-Wook Han, Seongwook Hur, Seung-Ho Eisen, Howard J. Kim, Hyungseop J Korean Med Sci Original Article BACKGROUNDS: The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes. METHODS: This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed. RESULTS: A total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P = 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P = 0.008). CONCLUSION: The increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19. The Korean Academy of Medical Sciences 2020-09-24 /pmc/articles/PMC7550234/ /pubmed/33045772 http://dx.doi.org/10.3346/jkms.2020.35.e349 Text en © 2020 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, In-Cheol Song, Jin Eun Lee, Hee Jung Park, Jeong-Ho Hyun, Miri Lee, Ji Yeon Kim, Hyun Ah Kwon, Yong Shik Park, Jae Seok Youn, Jong-Chan Hwang, Jongmin Lee, Cheol Hyun Cho, Yun-Kyeong Park, Hyoung-Seob Yoon, Hyuck-Jun Nam, Chang-Wook Han, Seongwook Hur, Seung-Ho Eisen, Howard J. Kim, Hyungseop The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 |
title | The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 |
title_full | The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 |
title_fullStr | The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 |
title_full_unstemmed | The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 |
title_short | The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019 |
title_sort | implication of cardiac injury score on in-hospital mortality of coronavirus disease 2019 |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550234/ https://www.ncbi.nlm.nih.gov/pubmed/33045772 http://dx.doi.org/10.3346/jkms.2020.35.e349 |
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