The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties

INTRODUCTION: For drugs eliminated by glomerular filtration (GF), clearance (CL) is determined by GF rate (GFR) and the unbound fraction of the drug. When predicting CL of GF-eliminated drugs in children, instead of physiologically based pharmacokinetic (PBPK) methods that consider changes in both G...

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Detalles Bibliográficos
Autores principales: Cristea, Sinziana, Krekels, Elke H. J., Allegaert, Karel, Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550283/
https://www.ncbi.nlm.nih.gov/pubmed/32314184
http://dx.doi.org/10.1007/s40262-020-00890-2

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