A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor

Although pharmaco-epidemiological studies provided evidence for the anticancer potential of non-steroidal anti-inflammatory drugs (NSAIDs), the mechanism of their anti-cancer activity is not known. Several lines of evidence suggest that proline dehydrogenase/proline oxidase (PRODH/POX) may represent...

Descripción completa

Detalles Bibliográficos
Autores principales: Kazberuk, Adam, Zareba, Ilona, Palka, Jerzy, Surazynski, Arkadiusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550302/
https://www.ncbi.nlm.nih.gov/pubmed/32710395
http://dx.doi.org/10.1007/s43440-020-00140-z
_version_ 1783592946802622464
author Kazberuk, Adam
Zareba, Ilona
Palka, Jerzy
Surazynski, Arkadiusz
author_facet Kazberuk, Adam
Zareba, Ilona
Palka, Jerzy
Surazynski, Arkadiusz
author_sort Kazberuk, Adam
collection PubMed
description Although pharmaco-epidemiological studies provided evidence for the anticancer potential of non-steroidal anti-inflammatory drugs (NSAIDs), the mechanism of their anti-cancer activity is not known. Several lines of evidence suggest that proline dehydrogenase/proline oxidase (PRODH/POX) may represent a target for NSAIDs-dependent anti-cancer activity. PRODH/POX catalyzes conversion of proline into Δ1-pyrroline-5-carboxylate releasing ATP or reactive oxygen species for autophagy/apoptosis. Since NSAIDs are ligands of peroxisome proliferator-activated receptor (PPARs) and PPARs are implicated in PRODH/POX-dependent apoptosis we provided a hypothesis on the mechanism of NSAIDs-induced apoptosis in cancer cells.
format Online
Article
Text
id pubmed-7550302
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-75503022020-10-19 A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor Kazberuk, Adam Zareba, Ilona Palka, Jerzy Surazynski, Arkadiusz Pharmacol Rep Review Although pharmaco-epidemiological studies provided evidence for the anticancer potential of non-steroidal anti-inflammatory drugs (NSAIDs), the mechanism of their anti-cancer activity is not known. Several lines of evidence suggest that proline dehydrogenase/proline oxidase (PRODH/POX) may represent a target for NSAIDs-dependent anti-cancer activity. PRODH/POX catalyzes conversion of proline into Δ1-pyrroline-5-carboxylate releasing ATP or reactive oxygen species for autophagy/apoptosis. Since NSAIDs are ligands of peroxisome proliferator-activated receptor (PPARs) and PPARs are implicated in PRODH/POX-dependent apoptosis we provided a hypothesis on the mechanism of NSAIDs-induced apoptosis in cancer cells. Springer International Publishing 2020-07-24 2020 /pmc/articles/PMC7550302/ /pubmed/32710395 http://dx.doi.org/10.1007/s43440-020-00140-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Kazberuk, Adam
Zareba, Ilona
Palka, Jerzy
Surazynski, Arkadiusz
A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
title A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
title_full A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
title_fullStr A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
title_full_unstemmed A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
title_short A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
title_sort novel plausible mechanism of nsaids-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550302/
https://www.ncbi.nlm.nih.gov/pubmed/32710395
http://dx.doi.org/10.1007/s43440-020-00140-z
work_keys_str_mv AT kazberukadam anovelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT zarebailona anovelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT palkajerzy anovelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT surazynskiarkadiusz anovelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT kazberukadam novelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT zarebailona novelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT palkajerzy novelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor
AT surazynskiarkadiusz novelplausiblemechanismofnsaidsinducedapoptosisincancercellstheimplicationofprolineoxidaseandperoxisomeproliferatoractivatedreceptor

Ejemplares similares