Cargando…
Cellular senescence-mediated exacerbation of Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a progressive disease characterised by chronic muscle degeneration and inflammation. Our previously established DMD model rats (DMD rats) have a more severe disease phenotype than the broadly used mouse model. We aimed to investigate the role of senescence in DMD...
Autores principales: | Sugihara, Hidetoshi, Teramoto, Naomi, Nakamura, Katsuyuki, Shiga, Takanori, Shirakawa, Taku, Matsuo, Masafumi, Ogasawara, Masashi, Nishino, Ichizo, Matsuwaki, Takashi, Nishihara, Masugi, Yamanouchi, Keitaro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550355/ https://www.ncbi.nlm.nih.gov/pubmed/33046751 http://dx.doi.org/10.1038/s41598-020-73315-6 |
Ejemplares similares
-
Loss of p16/Ink4a drives high frequency of rhabdomyosarcoma in a rat model of Duchenne muscular dystrophy
por: TERAMOTO, Naomi, et al.
Publicado: (2021) -
Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy
por: Teramoto, Naomi, et al.
Publicado: (2020) -
Oxidative stress-mediated senescence in mesenchymal progenitor cells causes the loss of their fibro/adipogenic potential and abrogates myoblast fusion
por: Sugihara, Hidetoshi, et al.
Publicado: (2018) -
Progranulin deficiency leads to prolonged persistence of macrophages,
accompanied with myofiber hypertrophy in regenerating muscle
por: SUGIHARA, Hidetoshi, et al.
Publicado: (2017) -
Differentiation of skeletal muscle Mesenchymal progenitor cells to myofibroblasts is reversible
por: Takeuchi, Shiho, et al.
Publicado: (2020)