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Evaluation of objective visual quality in dry eye disease and corneal nerve changes
PURPOSE: To explore objective visual quality in dry eye diseases (DED) and the correlation between corneal nerves and objective visual quality. METHODS: Ninety-eight eyes of 49 patients with DED were included. Each patient was evaluated with the ocular surface disease index (OSDI), eyelid margin sig...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550365/ https://www.ncbi.nlm.nih.gov/pubmed/32617802 http://dx.doi.org/10.1007/s10792-020-01483-5 |
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author | Ma, Jiahui Wei, Shanshan Jiang, Xiaodan Chou, Yilin Wang, Yuexin Hao, Ran Yang, Jiarui Li, Xuemin |
author_facet | Ma, Jiahui Wei, Shanshan Jiang, Xiaodan Chou, Yilin Wang, Yuexin Hao, Ran Yang, Jiarui Li, Xuemin |
author_sort | Ma, Jiahui |
collection | PubMed |
description | PURPOSE: To explore objective visual quality in dry eye diseases (DED) and the correlation between corneal nerves and objective visual quality. METHODS: Ninety-eight eyes of 49 patients with DED were included. Each patient was evaluated with the ocular surface disease index (OSDI), eyelid margin signs and meibomian gland assessments; corneal staining; tear film breakup time (TBUT); tear meniscus height (TMH); in vivo confocal microscopic (IVCM); objective visual quality including the objective scatter index (OSI), mean objective scattering index (mOSI), modulation transfer function (MTF) cutoff value and Strehl ratio. RESULTS: A significant correlation was found between the OSDI and mOSI (r = 0.422, p = 0.005), MTF cutoff value (r = − 0.355, p = 0.020), and Strehl ratio (r = − 0.446, p = 0.003). The OSI was significantly correlated with TBUTf (r = − 0.213, p = 0.042). The mOSI, MTF cutoff value, Strehl ratio were correlated with eyelid margin signs and meibomian assessments. Additionally, there was a statistically significant correlation between corneal nerve length and the mOSI (r = − 0.239, p = 0.037), OSI (r = − 0.294, p = 0.028), MTF cutoff value(r = 0.282, p = 0.012), and Strehl ratio (r = 0.299, p = 0.008). CONCLUSIONS: Our study explored that objective visual quality was correlated with clinical symptoms and signs in DED patients. Furthermore, for the first time, our study explored the relationship between corneal nerves and objective visual quality and discovered that longer and wider corneal nerves were associated with better objective visual quality, which suggested that nerve changes may be a factor that related to poor visual quality in DED patients. |
format | Online Article Text |
id | pubmed-7550365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-75503652020-10-19 Evaluation of objective visual quality in dry eye disease and corneal nerve changes Ma, Jiahui Wei, Shanshan Jiang, Xiaodan Chou, Yilin Wang, Yuexin Hao, Ran Yang, Jiarui Li, Xuemin Int Ophthalmol Original Paper PURPOSE: To explore objective visual quality in dry eye diseases (DED) and the correlation between corneal nerves and objective visual quality. METHODS: Ninety-eight eyes of 49 patients with DED were included. Each patient was evaluated with the ocular surface disease index (OSDI), eyelid margin signs and meibomian gland assessments; corneal staining; tear film breakup time (TBUT); tear meniscus height (TMH); in vivo confocal microscopic (IVCM); objective visual quality including the objective scatter index (OSI), mean objective scattering index (mOSI), modulation transfer function (MTF) cutoff value and Strehl ratio. RESULTS: A significant correlation was found between the OSDI and mOSI (r = 0.422, p = 0.005), MTF cutoff value (r = − 0.355, p = 0.020), and Strehl ratio (r = − 0.446, p = 0.003). The OSI was significantly correlated with TBUTf (r = − 0.213, p = 0.042). The mOSI, MTF cutoff value, Strehl ratio were correlated with eyelid margin signs and meibomian assessments. Additionally, there was a statistically significant correlation between corneal nerve length and the mOSI (r = − 0.239, p = 0.037), OSI (r = − 0.294, p = 0.028), MTF cutoff value(r = 0.282, p = 0.012), and Strehl ratio (r = 0.299, p = 0.008). CONCLUSIONS: Our study explored that objective visual quality was correlated with clinical symptoms and signs in DED patients. Furthermore, for the first time, our study explored the relationship between corneal nerves and objective visual quality and discovered that longer and wider corneal nerves were associated with better objective visual quality, which suggested that nerve changes may be a factor that related to poor visual quality in DED patients. Springer Netherlands 2020-07-02 2020 /pmc/articles/PMC7550365/ /pubmed/32617802 http://dx.doi.org/10.1007/s10792-020-01483-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Paper Ma, Jiahui Wei, Shanshan Jiang, Xiaodan Chou, Yilin Wang, Yuexin Hao, Ran Yang, Jiarui Li, Xuemin Evaluation of objective visual quality in dry eye disease and corneal nerve changes |
title | Evaluation of objective visual quality in dry eye disease and corneal nerve changes |
title_full | Evaluation of objective visual quality in dry eye disease and corneal nerve changes |
title_fullStr | Evaluation of objective visual quality in dry eye disease and corneal nerve changes |
title_full_unstemmed | Evaluation of objective visual quality in dry eye disease and corneal nerve changes |
title_short | Evaluation of objective visual quality in dry eye disease and corneal nerve changes |
title_sort | evaluation of objective visual quality in dry eye disease and corneal nerve changes |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550365/ https://www.ncbi.nlm.nih.gov/pubmed/32617802 http://dx.doi.org/10.1007/s10792-020-01483-5 |
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