Cargando…
Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility
Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects o...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550565/ https://www.ncbi.nlm.nih.gov/pubmed/33046800 http://dx.doi.org/10.1038/s41598-020-74012-0 |
_version_ | 1783592990854348800 |
---|---|
author | Schulte, Alina Thiel, Christiane M. Gieseler, Anja Tahden, Maike Colonius, Hans Rosemann, Stephanie |
author_facet | Schulte, Alina Thiel, Christiane M. Gieseler, Anja Tahden, Maike Colonius, Hans Rosemann, Stephanie |
author_sort | Schulte, Alina |
collection | PubMed |
description | Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing thresholds and audio-visual integration on resting state functional connectivity. We analysed a large set of resting state data of 65 elderly participants with a widely varying degree of untreated hearing loss. Audio-visual integration, as gauged with the McGurk effect, increased with progressing hearing thresholds. On the neural level, McGurk illusions were negatively related to functional coupling between motor and auditory regions. Similarly, connectivity of the dorsal attention network to sensorimotor and primary motor cortices was reduced with increasing hearing loss. The same effect was obtained for connectivity between the salience network and visual cortex. Our findings suggest that with progressing untreated age-related hearing loss, functional coupling at rest declines, affecting connectivity of brain networks and areas associated with attentional, visual, sensorimotor and motor processes. Especially connectivity reductions between auditory and motor areas were related to stronger audio-visual integration found with increasing hearing loss. |
format | Online Article Text |
id | pubmed-7550565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-75505652020-10-14 Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility Schulte, Alina Thiel, Christiane M. Gieseler, Anja Tahden, Maike Colonius, Hans Rosemann, Stephanie Sci Rep Article Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing thresholds and audio-visual integration on resting state functional connectivity. We analysed a large set of resting state data of 65 elderly participants with a widely varying degree of untreated hearing loss. Audio-visual integration, as gauged with the McGurk effect, increased with progressing hearing thresholds. On the neural level, McGurk illusions were negatively related to functional coupling between motor and auditory regions. Similarly, connectivity of the dorsal attention network to sensorimotor and primary motor cortices was reduced with increasing hearing loss. The same effect was obtained for connectivity between the salience network and visual cortex. Our findings suggest that with progressing untreated age-related hearing loss, functional coupling at rest declines, affecting connectivity of brain networks and areas associated with attentional, visual, sensorimotor and motor processes. Especially connectivity reductions between auditory and motor areas were related to stronger audio-visual integration found with increasing hearing loss. Nature Publishing Group UK 2020-10-12 /pmc/articles/PMC7550565/ /pubmed/33046800 http://dx.doi.org/10.1038/s41598-020-74012-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Schulte, Alina Thiel, Christiane M. Gieseler, Anja Tahden, Maike Colonius, Hans Rosemann, Stephanie Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility |
title | Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility |
title_full | Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility |
title_fullStr | Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility |
title_full_unstemmed | Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility |
title_short | Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility |
title_sort | reduced resting state functional connectivity with increasing age-related hearing loss and mcgurk susceptibility |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550565/ https://www.ncbi.nlm.nih.gov/pubmed/33046800 http://dx.doi.org/10.1038/s41598-020-74012-0 |
work_keys_str_mv | AT schultealina reducedrestingstatefunctionalconnectivitywithincreasingagerelatedhearinglossandmcgurksusceptibility AT thielchristianem reducedrestingstatefunctionalconnectivitywithincreasingagerelatedhearinglossandmcgurksusceptibility AT gieseleranja reducedrestingstatefunctionalconnectivitywithincreasingagerelatedhearinglossandmcgurksusceptibility AT tahdenmaike reducedrestingstatefunctionalconnectivitywithincreasingagerelatedhearinglossandmcgurksusceptibility AT coloniushans reducedrestingstatefunctionalconnectivitywithincreasingagerelatedhearinglossandmcgurksusceptibility AT rosemannstephanie reducedrestingstatefunctionalconnectivitywithincreasingagerelatedhearinglossandmcgurksusceptibility |