Cargando…

High-throughput mutagenesis reveals unique structural features of human ADAR1

Adenosine Deaminases that act on RNA (ADARs) are enzymes that catalyze adenosine to inosine conversion in dsRNA, a common form of RNA editing. Mutations in the human ADAR1 gene are known to cause disease and recent studies have identified ADAR1 as a potential therapeutic target for a subset of cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, SeHee, Doherty, Erin E., Xie, Yixuan, Padyana, Anil K., Fang, Fang, Zhang, Yue, Karki, Agya, Lebrilla, Carlito B., Siegel, Justin B., Beal, Peter A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550611/ https://www.ncbi.nlm.nih.gov/pubmed/33046702 http://dx.doi.org/10.1038/s41467-020-18862-2

Ejemplares similares

ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site
por: Doherty, Erin E, et al.
Publicado: (2022)

Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method
por: Wang, Yuru, et al.
Publicado: (2016)

High-throughput glycomic analyses reveal unique oligosaccharide profiles of canine and feline milk samples
por: Wrigglesworth, David J., et al.
Publicado: (2020)

Nucleoside analogs in ADAR guide strands targeting 5′-UA̲ sites
por: Brinkman, Hannah F., et al.
Publicado: (2022)

Characterization of Cell Glycocalyx with Mass Spectrometry Methods
por: Li, Qiongyu, et al.
Publicado: (2019)

Identification of potential sialic acid binding proteins on cell membranes by proximity chemical labeling
por: Li, Qiongyu, et al.
Publicado: (2019)

N-Glycomic Analysis of the Cell Shows Specific Effects of Glycosyl Transferase Inhibitors
por: Zhou, Qingwen, et al.
Publicado: (2021)

A proximity labeling method for protein–protein interactions on cell membrane
por: Li, Qiongyu, et al.
Publicado: (2022)

Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
por: Liu, Xin, et al.
Publicado: (2021)

Determination of the glycoprotein specificity of lectins on cell membranes through oxidative proteomics
por: Xie, Yixuan, et al.
Publicado: (2020)

A high-throughput screen to identify enhancers of ADAR-mediated RNA-editing
por: Garncarz, Wojciech, et al.
Publicado: (2013)

Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer’s disease
por: Tang, Xinyu, et al.
Publicado: (2023)

Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2
por: Phelps, Kelly J., et al.
Publicado: (2015)

Squid express conserved ADAR orthologs that possess novel features
por: Vallecillo-Viejo, Isabel C., et al.
Publicado: (2023)

High throughput mutagenesis and screening for yeast engineering
por: Holland, Kendreze, et al.
Publicado: (2022)

The ADAR protein family
por: Savva, Yiannis A, et al.
Publicado: (2012)

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms
por: Kleinova, Renata, et al.
Publicado: (2023)

Developments in the Identification of Glycan Biomarkers for the Detection of Cancer
por: Ruhaak, L. Renee, et al.
Publicado: (2013)

Adenolipoma of the Breast: A Case Report
por: Karki, Samriddhi, et al.
Publicado: (2021)

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
por: Matthews, Melissa M., et al.
Publicado: (2016)

Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries
por: Fritzell, Kajsa, et al.
Publicado: (2019)

ZBP1 contributes to interferonopathies caused by impaired ADAR1 function
por: Fang, Xiuwu, et al.
Publicado: (2022)

In-Depth Method for the Characterization of Glycosylation in Manufactured Recombinant Monoclonal Antibody Drugs
por: Song, Ting, et al.
Publicado: (2014)

High-throughput mutagenesis using a two-fragment PCR approach
por: Heydenreich, Franziska M., et al.
Publicado: (2017)

High-throughput screening to identify potential inhibitors of the Zα domain of the adenosine deaminase 1 (ADAR1)
por: Choudhry, Hani
Publicado: (2021)

Diet affects glycosylation of serum proteins in women at risk for cardiometabolic disease
por: Kim, Tyler, et al.
Publicado: (2021)

Glycan–protein cross-linking mass spectrometry reveals sialic acid-mediated protein networks on cell surfaces
por: Xie, Yixuan, et al.
Publicado: (2021)

Intact glycosphingolipidomic analysis of the cell membrane during differentiation yields extensive glycan and lipid changes
por: Wong, Maurice, et al.
Publicado: (2018)

Author Correction: Intact glycosphingolipidomic analysis of the cell membrane during differentiation yields extensive glycan and lipid changes
por: Wong, Maurice, et al.
Publicado: (2020)

Host Cell Glycocalyx Remodeling Reveals SARS-CoV-2 Spike Protein Glycomic Binding Sites
por: Sheng, Ying, et al.
Publicado: (2022)

Promoting RNA editing by ADAR attraction
por: Danan-Gotthold, Miri, et al.
Publicado: (2017)

ADAR RNA editing below the backbone
por: Keegan, Liam, et al.
Publicado: (2017)

Milk: A Scientific Model for Diet and Health Research in the 21st Century
por: German, J. Bruce, et al.
Publicado: (2022)

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects
por: Keegan, Liam P., et al.
Publicado: (2011)

Optimal guideRNAs for re-directing deaminase activity of hADAR1 and hADAR2 in trans
por: Schneider, Marius F., et al.
Publicado: (2014)

RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells
por: Wang, Yuru, et al.
Publicado: (2019)

Integrating deep mutational scanning and low-throughput mutagenesis data to predict the impact of amino acid variants
por: Fu, Yunfan, et al.
Publicado: (2023)

On the analysis of glycomics mass spectrometry data via the regularized area under the ROC curve
por: Ye, Jingjing, et al.
Publicado: (2007)

Translating neonatal microbiome science into commercial innovation: metabolism of human milk oligosaccharides as a basis for probiotic efficacy in breast-fed infants
por: Mills, David A., et al.
Publicado: (2023)

Determinants of human milk oligosaccharides profiles of participants in the STRONG kids 2 cohort
por: Fan, Yuting, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bpbp0j5elmreb02muavpl0ohhi