An SCN1B Variant Affects Both Cardiac-Type (Na(V)1.5) and Brain-Type (Na(V)1.1) Sodium Currents and Contributes to Complex Concomitant Brain and Cardiac Disorders

Voltage-gated sodium (Na(V)) channels are transmembrane proteins that initiate and propagate neuronal and cardiac action potentials. Na(V) channel β subunits have been widely studied due to their modulatory role. Mice null for Scn1b, which encodes Na(V) β1 and β1b subunits, have defects in neuronal...

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Detalles Bibliográficos
Autores principales: Martinez-Moreno, Rebecca, Selga, Elisabet, Riuró, Helena, Carreras, David, Parnes, Mered, Srinivasan, Chandra, Wangler, Michael F., Pérez, Guillermo J., Scornik, Fabiana S., Brugada, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550680/
https://www.ncbi.nlm.nih.gov/pubmed/33134290
http://dx.doi.org/10.3389/fcell.2020.528742

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