Cargando…

STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation

Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate and poor prognosis. KRAS, TP53, CDKN2A, and SMAD4 are driver genes of PDAC and 30–75% patients have mutations in at least two of these four genes. Herein, we analyzed the relationship between these genes and prognosis of 762 patients...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Shanshan, Chen, Xiao, Xu, Xiangxiang, Zheng, Chenlei, Huang, Wenqian, Zhou, Yi, Akuetteh, Percy David Papa, Yang, Hongbao, Shi, Keqing, Chen, Bicheng, Zhang, Qiyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550692/ https://www.ncbi.nlm.nih.gov/pubmed/33134183 http://dx.doi.org/10.3389/fonc.2020.594224

Ejemplares similares

Differentiating TP53 Mutation Status in Pancreatic Ductal Adenocarcinoma Using Multiparametric MRI-Derived Radiomics
por: Gao, Jing, et al.
Publicado: (2021)

SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability
por: Yu, Miao, et al.
Publicado: (2020)

DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling
por: Zhou, Xiang, et al.
Publicado: (2019)

Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
por: Hori, Yasuki, et al.
Publicado: (2015)

On Strapping the Chest in Phthisis
por: McCrea, John
Publicado: (1874)

A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients
por: Saha, Gourab, et al.
Publicado: (2020)

TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma
por: Zhou, Yiran, et al.
Publicado: (2023)

Analysis of TP53 gene and particular infrastructural alterations in invasive ductal mammary carcinoma
por: Mihalcea, Corina Elena, et al.
Publicado: (2020)

Genetic alterations of KRAS and TP53 in intrahepatic cholangiocarcinoma associated with poor prognosis
por: Peng, Jianbo, et al.
Publicado: (2023)

Correction: Impact of TP53 Codon 72 and MDM2 SNP 309 Polymorphisms in Pancreatic Ductal Adenocarcinoma
Publicado: (2015)

Unexpected Interactions between Alkyl Straps and Pyridine Ligands in Sulfur-Strapped Porphyrin Nanorings
por: Roche, Cécile, et al.
Publicado: (2017)

Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
por: Tesio, Melania
Publicado: (2023)

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis
por: Leroy, Bernard, et al.
Publicado: (2013)

(Boot)Strapping The Interlock Systems
por: Wenninger, J
Publicado: (2004)

St Dalmas Hospital Strapping
Publicado: (1888)

On the Treatment of Ulcers of the Legs by Strapping
por: Hutchison, A. Copland
Publicado: (1821)

TP53 R273C Mutation Is Associated With Poor Prognosis in LGG Patients
por: Zhang, Jian, et al.
Publicado: (2022)

p53/TP53 Status Assessment in Gastroesophageal Adenocarcinoma
por: Boldrin, Elisa, et al.
Publicado: (2023)

Mutation of the TP53 gene and allelic imbalance at chromosome 17p13 in ductal carcinoma in situ.
por: Munn, K. E., et al.
Publicado: (1996)

Wild-Type TP53 Predicts Poor Prognosis in Patients with Gastric Cancer
por: Deng, Wenhong, et al.
Publicado: (2021)

Tp53 disruptions: is there a marker of poor prognosis in chronic lymphoproliferative disorders?
por: Cencini, Emanuele, et al.
Publicado: (2021)

Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis
por: Hong, Weilong, et al.
Publicado: (2019)

TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
por: Wang, Haiwei, et al.
Publicado: (2022)

A first case of ductal adenocarcinoma of the prostate having characteristics of neuroendocrine phenotype with PTEN, RB1 and TP53 alterations
por: Kobayashi, Hiroaki, et al.
Publicado: (2021)

SLC45A4 promotes glycolysis and prevents AMPK/ULK1‐induced autophagy in TP53 mutant pancreatic ductal adenocarcinoma
por: Chen, Wenying, et al.
Publicado: (2021)

Making straps from small movements
por: Dove, Alan W.
Publicado: (2002)

Mr. Warnock, on Adhesive Straps in Ulcers
por: Warnock, W.
Publicado: (1808)

Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements
por: Trauernicht, Max, et al.
Publicado: (2023)

KRAS(G12D) and TP53(R167H) Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs
por: Principe, Daniel R., et al.
Publicado: (2018)

TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors
por: Kim, Ji‐Yeon, et al.
Publicado: (2023)

Impact of TP53 mutations in breast cancer: Clinicopathological features and prognosisImpact of TP53 mutations in breast CA
por: Li, Xuerui, et al.
Publicado: (2020)

Alterations of TP53 in microdissected transitional cell carcinoma of the human urinary bladder: high frequency of TP53 accumulation in the absence of detected mutations is associated with poor prognosis.
por: Abdel-Fattah, R., et al.
Publicado: (1998)

S127: DELTATP73 IMPOSES TP53 MUTANT-LIKE PHENOTYPES INCLUDING DRUG RESISTANCE AND POOR PROGNOSIS ON TP53-WILD TYPE ACUTE MYELOID LEUKEMIA.
por: Pereira-Martins, Diego A, et al.
Publicado: (2023)

Long noncoding RNA TP53TG1 promotes pancreatic ductal adenocarcinoma development by acting as a molecular sponge of microRNA‐96
por: Zhang, Yufeng, et al.
Publicado: (2019)

Overexpression of RBBP6, Alone or Combined with Mutant TP53, Is Predictive of Poor Prognosis in Colon Cancer
por: Chen, Jian, et al.
Publicado: (2013)

C-STrap Sample Preparation Method—In-Situ Cysteinyl Peptide Capture for Bottom-Up Proteomics Analysis in the STrap Format
por: Zougman, Alexandre, et al.
Publicado: (2015)

Bra strap orientations and designs to minimise bra strap discomfort and pressure during sport and exercise in women with large breasts
por: Coltman, Celeste E, et al.
Publicado: (2015)

Major Vault Protein (MVP) Associated With BRAF (V600E) Mutation Is an Immune Microenvironment-Related Biomarker Promoting the Progression of Papillary Thyroid Cancer via MAPK/ERK and PI3K/AKT Pathways
por: Dong, Xubin, et al.
Publicado: (2022)

The TP53 fertility network
por: Paskulin, Diego d’Avila, et al.
Publicado: (2012)

TP53: an oncogene in disguise
por: Soussi, T, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_932s0ipiu8iq58m2f49n7aqdjq