The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis

Intestinal epithelial cells (IECs) exist in a metabolic state of low oxygen tension termed “physiologic hypoxia.” An important factor in maintaining intestinal homeostasis is the transcription factor hypoxia-inducible factor (HIF), which is stabilized under hypoxic conditions and mediates IEC homeos...

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Detalles Bibliográficos
Autores principales: Dowdell, Alexander S., Cartwright, Ian M., Goldberg, Matthew S., Kostelecky, Rachael, Ross, Tyler, Welch, Nichole, Glover, Louis E., Colgan, Sean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550696/
https://www.ncbi.nlm.nih.gov/pubmed/32726170
http://dx.doi.org/10.1091/mbc.E20-05-0291

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