Cargando…

Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population

Background and aims: The pathophysiology of hippocampal enlarged perivascular spaces (H-EPVS) and its relationship to cognitive impairment is largely unknown. This study aimed to investigate the relationship between H-EPVS and cognition in non-dementic elderly population. Methods: A total of 109 sub...

Descripción completa

Detalles Bibliográficos
Autores principales: Sim, Jae Eun, Park, Moo-Seok, Shin, Hee-Young, Jang, Hyun-Soon, Won, Hong-Hee, Seo, Sang Won, Seo, Woo-Keun, Kim, Byoung Joon, Kim, Gyeong-Moon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550712/
https://www.ncbi.nlm.nih.gov/pubmed/33133000
http://dx.doi.org/10.3389/fneur.2020.542511
_version_ 1783593024175996928
author Sim, Jae Eun
Park, Moo-Seok
Shin, Hee-Young
Jang, Hyun-Soon
Won, Hong-Hee
Seo, Sang Won
Seo, Woo-Keun
Kim, Byoung Joon
Kim, Gyeong-Moon
author_facet Sim, Jae Eun
Park, Moo-Seok
Shin, Hee-Young
Jang, Hyun-Soon
Won, Hong-Hee
Seo, Sang Won
Seo, Woo-Keun
Kim, Byoung Joon
Kim, Gyeong-Moon
author_sort Sim, Jae Eun
collection PubMed
description Background and aims: The pathophysiology of hippocampal enlarged perivascular spaces (H-EPVS) and its relationship to cognitive impairment is largely unknown. This study aimed to investigate the relationship between H-EPVS and cognition in non-dementic elderly population. Methods: A total of 109 subjects were prospectively enrolled. The eligibilities for inclusion were age from 55 to 85 years and Mini-Mental Status Examination score of ≥26. The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Montreal Cognitive Assessment, transcranial Doppler (TCD), and brain magnetic resonance imaging results were evaluated. H-EPVS was categorized in a three-degree scale: degree 0 (no), degree 1 (1,2), and degree 2 (>2). The associations between H-EPVS and TCD parameters/cognitive test profiles were analyzed. Results: The mean age was 65.2 years, and 52.3% subjects were men. H-EPVS was found to be associated with age (degree 2 vs. degree 1 vs. degree 0, 69.20 ± 6.93 vs. 65.70 ± 5.75 vs. 63.80 ± 5.43; p = 0.030) and ADAS-Cog memory score (degree 2 vs. degree 1 vs. degree 0, 14.88 ± 4.27 vs. 12.49 ± 4.56 vs. 11.4 ± 4.23; p = 0.037). However, the pulsatility index was not related to the degree of H-EPVS. Multivariate analysis revealed medial temporal atrophy (MTA) scale score was independently associated with ADAS-Cog memory score (MTA scale sum ≥4, p = 0.011) but not with the degree of H-EPVS. MTA scale score showed correlation with H-EPVS (r = 0.273, p = 0.004). Conclusions: Aging was associated with the development of H-EPVS in non-dementic elderly population. Memory function was found to be associated with MTA but not with the degree of H-EPVS.
format Online
Article
Text
id pubmed-7550712
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-75507122020-10-29 Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population Sim, Jae Eun Park, Moo-Seok Shin, Hee-Young Jang, Hyun-Soon Won, Hong-Hee Seo, Sang Won Seo, Woo-Keun Kim, Byoung Joon Kim, Gyeong-Moon Front Neurol Neurology Background and aims: The pathophysiology of hippocampal enlarged perivascular spaces (H-EPVS) and its relationship to cognitive impairment is largely unknown. This study aimed to investigate the relationship between H-EPVS and cognition in non-dementic elderly population. Methods: A total of 109 subjects were prospectively enrolled. The eligibilities for inclusion were age from 55 to 85 years and Mini-Mental Status Examination score of ≥26. The Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), Montreal Cognitive Assessment, transcranial Doppler (TCD), and brain magnetic resonance imaging results were evaluated. H-EPVS was categorized in a three-degree scale: degree 0 (no), degree 1 (1,2), and degree 2 (>2). The associations between H-EPVS and TCD parameters/cognitive test profiles were analyzed. Results: The mean age was 65.2 years, and 52.3% subjects were men. H-EPVS was found to be associated with age (degree 2 vs. degree 1 vs. degree 0, 69.20 ± 6.93 vs. 65.70 ± 5.75 vs. 63.80 ± 5.43; p = 0.030) and ADAS-Cog memory score (degree 2 vs. degree 1 vs. degree 0, 14.88 ± 4.27 vs. 12.49 ± 4.56 vs. 11.4 ± 4.23; p = 0.037). However, the pulsatility index was not related to the degree of H-EPVS. Multivariate analysis revealed medial temporal atrophy (MTA) scale score was independently associated with ADAS-Cog memory score (MTA scale sum ≥4, p = 0.011) but not with the degree of H-EPVS. MTA scale score showed correlation with H-EPVS (r = 0.273, p = 0.004). Conclusions: Aging was associated with the development of H-EPVS in non-dementic elderly population. Memory function was found to be associated with MTA but not with the degree of H-EPVS. Frontiers Media S.A. 2020-09-29 /pmc/articles/PMC7550712/ /pubmed/33133000 http://dx.doi.org/10.3389/fneur.2020.542511 Text en Copyright © 2020 Sim, Park, Shin, Jang, Won, Seo, Seo, Kim and Kim. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Sim, Jae Eun
Park, Moo-Seok
Shin, Hee-Young
Jang, Hyun-Soon
Won, Hong-Hee
Seo, Sang Won
Seo, Woo-Keun
Kim, Byoung Joon
Kim, Gyeong-Moon
Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
title Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
title_full Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
title_fullStr Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
title_full_unstemmed Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
title_short Correlation Between Hippocampal Enlarged Perivascular Spaces and Cognition in Non-dementic Elderly Population
title_sort correlation between hippocampal enlarged perivascular spaces and cognition in non-dementic elderly population
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550712/
https://www.ncbi.nlm.nih.gov/pubmed/33133000
http://dx.doi.org/10.3389/fneur.2020.542511
work_keys_str_mv AT simjaeeun correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT parkmooseok correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT shinheeyoung correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT janghyunsoon correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT wonhonghee correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT seosangwon correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT seowookeun correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT kimbyoungjoon correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation
AT kimgyeongmoon correlationbetweenhippocampalenlargedperivascularspacesandcognitioninnondementicelderlypopulation