Cargando…
Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3
Objective: To evaluate the characteristics of F-wave in spinocerebellar ataxia type 3 (SCA3) patients and preclinical carriers of SCA3 gene mutation (PreSCA3), and explore the relationship between disease severity and F-wave parameters and evaluate F-wave parameters as potential biomarkers for monit...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550721/ https://www.ncbi.nlm.nih.gov/pubmed/33117264 http://dx.doi.org/10.3389/fneur.2020.571341 |
_version_ | 1783593026293071872 |
---|---|
author | Cai, Qiong Xu, Wenxiao Liao, Songjie Liang, Yinxing Wu, Chao Li, Xunhua |
author_facet | Cai, Qiong Xu, Wenxiao Liao, Songjie Liang, Yinxing Wu, Chao Li, Xunhua |
author_sort | Cai, Qiong |
collection | PubMed |
description | Objective: To evaluate the characteristics of F-wave in spinocerebellar ataxia type 3 (SCA3) patients and preclinical carriers of SCA3 gene mutation (PreSCA3), and explore the relationship between disease severity and F-wave parameters and evaluate F-wave parameters as potential biomarkers for monitoring of disease progression in SCA3. Methods: We performed F-wave recordings in median, ulnar and tibial nerves of 39 SCA3 patients, 20 PreSCA3, and 27 healthy controls, and compared F-wave parameters between them. Results: In all nerves studied, the mean F-wave amplitude, maximum F-wave amplitude, and F/M amplitude ratio were significantly increased in the SCA3 patients in comparison with the normal controls. And the minimal F-wave latency of SCA3 patients was significantly prolonged and the F-wave persistence (%) was significantly decreased in the median nerve. For the PreSCA3, the maximum F-wave amplitude was significantly higher than normal controls for both median, ulnar, and tibial nerves. The mean F-wave amplitude and F/M amplitude ratio in all nerves were comparable between PreSCA3 and normal controls. The frequency of giant F-wave and frequency of patients with giant F-wave were similar between PreSCA3 and SCA3. The values of F/M amplitude ratio in both median, ulnar, and tibial nerves were correlated positively with disease severity and disease duration. Conclusion: Significant F-wave abnormalities occur in patients with SCA3, even in PreSCA3. F-wave may therefore reveal subclinical alterations and provide objective parameters for evaluating the progression of SCA3. |
format | Online Article Text |
id | pubmed-7550721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75507212020-10-27 Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 Cai, Qiong Xu, Wenxiao Liao, Songjie Liang, Yinxing Wu, Chao Li, Xunhua Front Neurol Neurology Objective: To evaluate the characteristics of F-wave in spinocerebellar ataxia type 3 (SCA3) patients and preclinical carriers of SCA3 gene mutation (PreSCA3), and explore the relationship between disease severity and F-wave parameters and evaluate F-wave parameters as potential biomarkers for monitoring of disease progression in SCA3. Methods: We performed F-wave recordings in median, ulnar and tibial nerves of 39 SCA3 patients, 20 PreSCA3, and 27 healthy controls, and compared F-wave parameters between them. Results: In all nerves studied, the mean F-wave amplitude, maximum F-wave amplitude, and F/M amplitude ratio were significantly increased in the SCA3 patients in comparison with the normal controls. And the minimal F-wave latency of SCA3 patients was significantly prolonged and the F-wave persistence (%) was significantly decreased in the median nerve. For the PreSCA3, the maximum F-wave amplitude was significantly higher than normal controls for both median, ulnar, and tibial nerves. The mean F-wave amplitude and F/M amplitude ratio in all nerves were comparable between PreSCA3 and normal controls. The frequency of giant F-wave and frequency of patients with giant F-wave were similar between PreSCA3 and SCA3. The values of F/M amplitude ratio in both median, ulnar, and tibial nerves were correlated positively with disease severity and disease duration. Conclusion: Significant F-wave abnormalities occur in patients with SCA3, even in PreSCA3. F-wave may therefore reveal subclinical alterations and provide objective parameters for evaluating the progression of SCA3. Frontiers Media S.A. 2020-09-29 /pmc/articles/PMC7550721/ /pubmed/33117264 http://dx.doi.org/10.3389/fneur.2020.571341 Text en Copyright © 2020 Cai, Xu, Liao, Liang, Wu and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Cai, Qiong Xu, Wenxiao Liao, Songjie Liang, Yinxing Wu, Chao Li, Xunhua Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 |
title | Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 |
title_full | Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 |
title_fullStr | Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 |
title_full_unstemmed | Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 |
title_short | Clinical and Physiological Significance of F-Wave in Spinocerebellar Ataxia Type 3 |
title_sort | clinical and physiological significance of f-wave in spinocerebellar ataxia type 3 |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550721/ https://www.ncbi.nlm.nih.gov/pubmed/33117264 http://dx.doi.org/10.3389/fneur.2020.571341 |
work_keys_str_mv | AT caiqiong clinicalandphysiologicalsignificanceoffwaveinspinocerebellarataxiatype3 AT xuwenxiao clinicalandphysiologicalsignificanceoffwaveinspinocerebellarataxiatype3 AT liaosongjie clinicalandphysiologicalsignificanceoffwaveinspinocerebellarataxiatype3 AT liangyinxing clinicalandphysiologicalsignificanceoffwaveinspinocerebellarataxiatype3 AT wuchao clinicalandphysiologicalsignificanceoffwaveinspinocerebellarataxiatype3 AT lixunhua clinicalandphysiologicalsignificanceoffwaveinspinocerebellarataxiatype3 |