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Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes

The author's method of oligomer sums for analysis of oligomer compositions of eukaryotic and prokaryotic genomes is described. The use of this method revealed the existence of general rules for the cooperative oligomeric organization of a wide list of genomes. These rules are called hyperbolic...

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Autor principal: Petoukhov, Sergey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550895/
https://www.ncbi.nlm.nih.gov/pubmed/33065213
http://dx.doi.org/10.1016/j.biosystems.2020.104273
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author Petoukhov, Sergey V.
author_facet Petoukhov, Sergey V.
author_sort Petoukhov, Sergey V.
collection PubMed
description The author's method of oligomer sums for analysis of oligomer compositions of eukaryotic and prokaryotic genomes is described. The use of this method revealed the existence of general rules for the cooperative oligomeric organization of a wide list of genomes. These rules are called hyperbolic because they are associated with hyperbolic sequences including the harmonic progression 1, 1/2, 1/3, .., 1/n. These rules are demonstrated by examples of quantitative analysis of many genomes from the human genome to the genomes of archaea and bacteria. The hyperbolic (harmonic) rules, speaking about the existence of algebraic invariants in full genomic sequences, are considered as candidates for the role of universal rules for the cooperative organization of genomes. The results concerns additionally the problem of the origin of life. The described phenomenological results were obtained as consequences of the previously published author's quantum-information model of long DNA sequences. The oligomer sums method was also applied to the analysis of long genes and viruses including the COVID-19 virus; this revealed, in characteristics of many of them, the phenomenon of such rhythmically repeating deviations from model hyperbolic sequences, which are associated with DNA triplets. In addition, an application of the oligomer sums method is shown to the analysis of amino acid sequences in long proteins like the protein Titin. The topics of the algebraic harmony in living bodies and of the quantum-information approach in biology are discussed.
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spelling pubmed-75508952020-10-13 Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes Petoukhov, Sergey V. Biosystems Article The author's method of oligomer sums for analysis of oligomer compositions of eukaryotic and prokaryotic genomes is described. The use of this method revealed the existence of general rules for the cooperative oligomeric organization of a wide list of genomes. These rules are called hyperbolic because they are associated with hyperbolic sequences including the harmonic progression 1, 1/2, 1/3, .., 1/n. These rules are demonstrated by examples of quantitative analysis of many genomes from the human genome to the genomes of archaea and bacteria. The hyperbolic (harmonic) rules, speaking about the existence of algebraic invariants in full genomic sequences, are considered as candidates for the role of universal rules for the cooperative organization of genomes. The results concerns additionally the problem of the origin of life. The described phenomenological results were obtained as consequences of the previously published author's quantum-information model of long DNA sequences. The oligomer sums method was also applied to the analysis of long genes and viruses including the COVID-19 virus; this revealed, in characteristics of many of them, the phenomenon of such rhythmically repeating deviations from model hyperbolic sequences, which are associated with DNA triplets. In addition, an application of the oligomer sums method is shown to the analysis of amino acid sequences in long proteins like the protein Titin. The topics of the algebraic harmony in living bodies and of the quantum-information approach in biology are discussed. Elsevier B.V. 2020-12 2020-10-13 /pmc/articles/PMC7550895/ /pubmed/33065213 http://dx.doi.org/10.1016/j.biosystems.2020.104273 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Petoukhov, Sergey V.
Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
title Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
title_full Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
title_fullStr Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
title_full_unstemmed Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
title_short Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
title_sort hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550895/
https://www.ncbi.nlm.nih.gov/pubmed/33065213
http://dx.doi.org/10.1016/j.biosystems.2020.104273
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