Cargando…
Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and hi...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550990/ https://www.ncbi.nlm.nih.gov/pubmed/32962215 http://dx.doi.org/10.3390/v12091047 |
_version_ | 1783593083493941248 |
---|---|
author | Zanotto, Elisa Allesina, Anna Barreca, Antonella Sidoti, Francesca Gallo, Ester Bottino, Paolo Iannaccone, Marco Bianco, Gabriele Biancone, Luigi Cavallo, Rossana Costa, Cristina |
author_facet | Zanotto, Elisa Allesina, Anna Barreca, Antonella Sidoti, Francesca Gallo, Ester Bottino, Paolo Iannaccone, Marco Bianco, Gabriele Biancone, Luigi Cavallo, Rossana Costa, Cristina |
author_sort | Zanotto, Elisa |
collection | PubMed |
description | Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and histology remain the criterion standard for diagnosing PVAN. Methods: All consecutive renal biopsies with the diagnosis of PVAN carried out at the University Hospital City of Health and Science of Turin over a five-years period were studied. Renal allograft biopsy was performed due to renal function alterations associated to medium-high polyomavirus BK (BKV)-DNA levels on plasma specimen. Results: A total of 21 patients underwent a first biopsy to diagnose a possible BKV nephropathy, in 18, a second biopsy was made, in eight, a third biopsy, and finally, three underwent the fourth renal biopsy; following the results of each biopsies, immunosuppressant agents dosages were modified in order to reduce the effect of PVAN. Conclusions: In this study, the clinical and histological features of 21 kidney transplant recipients with BKV reactivation and development of PVAN are described. To date, the only treatment for PVAN consists in the reduction of immunosuppressive agents, constantly monitoring viral load. |
format | Online Article Text |
id | pubmed-7550990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75509902020-10-15 Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 Zanotto, Elisa Allesina, Anna Barreca, Antonella Sidoti, Francesca Gallo, Ester Bottino, Paolo Iannaccone, Marco Bianco, Gabriele Biancone, Luigi Cavallo, Rossana Costa, Cristina Viruses Article Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and histology remain the criterion standard for diagnosing PVAN. Methods: All consecutive renal biopsies with the diagnosis of PVAN carried out at the University Hospital City of Health and Science of Turin over a five-years period were studied. Renal allograft biopsy was performed due to renal function alterations associated to medium-high polyomavirus BK (BKV)-DNA levels on plasma specimen. Results: A total of 21 patients underwent a first biopsy to diagnose a possible BKV nephropathy, in 18, a second biopsy was made, in eight, a third biopsy, and finally, three underwent the fourth renal biopsy; following the results of each biopsies, immunosuppressant agents dosages were modified in order to reduce the effect of PVAN. Conclusions: In this study, the clinical and histological features of 21 kidney transplant recipients with BKV reactivation and development of PVAN are described. To date, the only treatment for PVAN consists in the reduction of immunosuppressive agents, constantly monitoring viral load. MDPI 2020-09-20 /pmc/articles/PMC7550990/ /pubmed/32962215 http://dx.doi.org/10.3390/v12091047 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zanotto, Elisa Allesina, Anna Barreca, Antonella Sidoti, Francesca Gallo, Ester Bottino, Paolo Iannaccone, Marco Bianco, Gabriele Biancone, Luigi Cavallo, Rossana Costa, Cristina Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 |
title | Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 |
title_full | Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 |
title_fullStr | Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 |
title_full_unstemmed | Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 |
title_short | Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 |
title_sort | renal allograft biopsies with polyomavirus bk nephropathy: turin transplant center, 2015–19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550990/ https://www.ncbi.nlm.nih.gov/pubmed/32962215 http://dx.doi.org/10.3390/v12091047 |
work_keys_str_mv | AT zanottoelisa renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT allesinaanna renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT barrecaantonella renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT sidotifrancesca renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT galloester renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT bottinopaolo renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT iannacconemarco renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT biancogabriele renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT bianconeluigi renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT cavallorossana renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 AT costacristina renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519 |