Cargando…

Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19

Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zanotto, Elisa, Allesina, Anna, Barreca, Antonella, Sidoti, Francesca, Gallo, Ester, Bottino, Paolo, Iannaccone, Marco, Bianco, Gabriele, Biancone, Luigi, Cavallo, Rossana, Costa, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550990/
https://www.ncbi.nlm.nih.gov/pubmed/32962215
http://dx.doi.org/10.3390/v12091047
_version_ 1783593083493941248
author Zanotto, Elisa
Allesina, Anna
Barreca, Antonella
Sidoti, Francesca
Gallo, Ester
Bottino, Paolo
Iannaccone, Marco
Bianco, Gabriele
Biancone, Luigi
Cavallo, Rossana
Costa, Cristina
author_facet Zanotto, Elisa
Allesina, Anna
Barreca, Antonella
Sidoti, Francesca
Gallo, Ester
Bottino, Paolo
Iannaccone, Marco
Bianco, Gabriele
Biancone, Luigi
Cavallo, Rossana
Costa, Cristina
author_sort Zanotto, Elisa
collection PubMed
description Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and histology remain the criterion standard for diagnosing PVAN. Methods: All consecutive renal biopsies with the diagnosis of PVAN carried out at the University Hospital City of Health and Science of Turin over a five-years period were studied. Renal allograft biopsy was performed due to renal function alterations associated to medium-high polyomavirus BK (BKV)-DNA levels on plasma specimen. Results: A total of 21 patients underwent a first biopsy to diagnose a possible BKV nephropathy, in 18, a second biopsy was made, in eight, a third biopsy, and finally, three underwent the fourth renal biopsy; following the results of each biopsies, immunosuppressant agents dosages were modified in order to reduce the effect of PVAN. Conclusions: In this study, the clinical and histological features of 21 kidney transplant recipients with BKV reactivation and development of PVAN are described. To date, the only treatment for PVAN consists in the reduction of immunosuppressive agents, constantly monitoring viral load.
format Online
Article
Text
id pubmed-7550990
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75509902020-10-15 Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19 Zanotto, Elisa Allesina, Anna Barreca, Antonella Sidoti, Francesca Gallo, Ester Bottino, Paolo Iannaccone, Marco Bianco, Gabriele Biancone, Luigi Cavallo, Rossana Costa, Cristina Viruses Article Background: In kidney transplant patients, polyomavirus-associated nephropathy (PVAN) represents a serious complication; the key factor for the development of PVAN is immunosuppression level and modulation of anti-rejection treatment represents the first line of intervention. Allograft biopsy and histology remain the criterion standard for diagnosing PVAN. Methods: All consecutive renal biopsies with the diagnosis of PVAN carried out at the University Hospital City of Health and Science of Turin over a five-years period were studied. Renal allograft biopsy was performed due to renal function alterations associated to medium-high polyomavirus BK (BKV)-DNA levels on plasma specimen. Results: A total of 21 patients underwent a first biopsy to diagnose a possible BKV nephropathy, in 18, a second biopsy was made, in eight, a third biopsy, and finally, three underwent the fourth renal biopsy; following the results of each biopsies, immunosuppressant agents dosages were modified in order to reduce the effect of PVAN. Conclusions: In this study, the clinical and histological features of 21 kidney transplant recipients with BKV reactivation and development of PVAN are described. To date, the only treatment for PVAN consists in the reduction of immunosuppressive agents, constantly monitoring viral load. MDPI 2020-09-20 /pmc/articles/PMC7550990/ /pubmed/32962215 http://dx.doi.org/10.3390/v12091047 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zanotto, Elisa
Allesina, Anna
Barreca, Antonella
Sidoti, Francesca
Gallo, Ester
Bottino, Paolo
Iannaccone, Marco
Bianco, Gabriele
Biancone, Luigi
Cavallo, Rossana
Costa, Cristina
Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
title Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
title_full Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
title_fullStr Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
title_full_unstemmed Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
title_short Renal Allograft Biopsies with Polyomavirus BK Nephropathy: Turin Transplant Center, 2015–19
title_sort renal allograft biopsies with polyomavirus bk nephropathy: turin transplant center, 2015–19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7550990/
https://www.ncbi.nlm.nih.gov/pubmed/32962215
http://dx.doi.org/10.3390/v12091047
work_keys_str_mv AT zanottoelisa renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT allesinaanna renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT barrecaantonella renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT sidotifrancesca renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT galloester renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT bottinopaolo renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT iannacconemarco renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT biancogabriele renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT bianconeluigi renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT cavallorossana renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519
AT costacristina renalallograftbiopsieswithpolyomavirusbknephropathyturintransplantcenter201519