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Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng

Black ginseng has various pharmacological activities, but only few studies have compared its pharmacological effects with those of red ginseng. We conducted an integrative systematic literature evaluation and developed a non-inferiority test based on the multivariate modeling approach to compare the...

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Autores principales: Lee, Dong-Kyu, Park, Seongoh, Long, Nguyen Phuoc, Min, Jung Eun, Kim, Hyung Min, Yang, Eugine, Lee, Seul Ji, Lim, Johan, Kwon, Sung Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551003/
https://www.ncbi.nlm.nih.gov/pubmed/32858896
http://dx.doi.org/10.3390/nu12092590
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author Lee, Dong-Kyu
Park, Seongoh
Long, Nguyen Phuoc
Min, Jung Eun
Kim, Hyung Min
Yang, Eugine
Lee, Seul Ji
Lim, Johan
Kwon, Sung Won
author_facet Lee, Dong-Kyu
Park, Seongoh
Long, Nguyen Phuoc
Min, Jung Eun
Kim, Hyung Min
Yang, Eugine
Lee, Seul Ji
Lim, Johan
Kwon, Sung Won
author_sort Lee, Dong-Kyu
collection PubMed
description Black ginseng has various pharmacological activities, but only few studies have compared its pharmacological effects with those of red ginseng. We conducted an integrative systematic literature evaluation and developed a non-inferiority test based on the multivariate modeling approach to compare the pharmacological effects of red ginseng and black ginseng. We searched reported studies on the pharmaceutical effects and composition of ginsenosides and assigned numeric scores using nonlinear principal component analysis, based on discretization measures for the included publications. Downstream weighted linear regression models were constructed to study the eight major biological activities that are generally known to be exhibited by red ginseng. Our statistical model, based on available ordinal information gathered from previous literature, helped in comparing the overlapping effects of black ginseng. Black ginseng showed antioxidant effects comparable to those of red ginseng; however, this variant was inferior to red ginseng in enhancing immunity, relieving fatigue, alleviating depression/anxiety, decreasing body fat, and reducing blood pressure. We have showed a cost-efficient method to indirectly evaluate the biological effects of ginseng products using data from published articles. This method can also be used to compare the nutritional and medicinal value of herbal medicines that share similar compositions of bioactive compounds.
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spelling pubmed-75510032020-10-16 Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng Lee, Dong-Kyu Park, Seongoh Long, Nguyen Phuoc Min, Jung Eun Kim, Hyung Min Yang, Eugine Lee, Seul Ji Lim, Johan Kwon, Sung Won Nutrients Article Black ginseng has various pharmacological activities, but only few studies have compared its pharmacological effects with those of red ginseng. We conducted an integrative systematic literature evaluation and developed a non-inferiority test based on the multivariate modeling approach to compare the pharmacological effects of red ginseng and black ginseng. We searched reported studies on the pharmaceutical effects and composition of ginsenosides and assigned numeric scores using nonlinear principal component analysis, based on discretization measures for the included publications. Downstream weighted linear regression models were constructed to study the eight major biological activities that are generally known to be exhibited by red ginseng. Our statistical model, based on available ordinal information gathered from previous literature, helped in comparing the overlapping effects of black ginseng. Black ginseng showed antioxidant effects comparable to those of red ginseng; however, this variant was inferior to red ginseng in enhancing immunity, relieving fatigue, alleviating depression/anxiety, decreasing body fat, and reducing blood pressure. We have showed a cost-efficient method to indirectly evaluate the biological effects of ginseng products using data from published articles. This method can also be used to compare the nutritional and medicinal value of herbal medicines that share similar compositions of bioactive compounds. MDPI 2020-08-26 /pmc/articles/PMC7551003/ /pubmed/32858896 http://dx.doi.org/10.3390/nu12092590 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Dong-Kyu
Park, Seongoh
Long, Nguyen Phuoc
Min, Jung Eun
Kim, Hyung Min
Yang, Eugine
Lee, Seul Ji
Lim, Johan
Kwon, Sung Won
Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
title Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
title_full Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
title_fullStr Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
title_full_unstemmed Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
title_short Research Quality-Based Multivariate Modeling for Comparison of the Pharmacological Effects of Black and Red Ginseng
title_sort research quality-based multivariate modeling for comparison of the pharmacological effects of black and red ginseng
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551003/
https://www.ncbi.nlm.nih.gov/pubmed/32858896
http://dx.doi.org/10.3390/nu12092590
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