CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR

The C-promoter binding factor-1 (CBF-1) is a potent and specific inhibitor of the human immunodeficiency virus (HIV)-1 LTR promoter. Here, we demonstrate that the knockdown of endogenous CBF-1 in latently infected primary CD4+ T cells, using specific small hairpin RNAs (shRNA), resulted in the react...

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Detalles Bibliográficos
Autores principales: Sharma, Adhikarimayum Lakhikumar, Hokello, Joseph, Sonti, Shilpa, Zicari, Sonia, Sun, Lin, Alqatawni, Aseel, Bukrinsky, Michael, Simon, Gary, Chauhan, Ashok, Daniel, Rene, Tyagi, Mudit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551090/
https://www.ncbi.nlm.nih.gov/pubmed/32961937
http://dx.doi.org/10.3390/v12091040

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