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Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs

Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and res...

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Autores principales: Mondal, Arijit, Bose, Sankhadip, Banerjee, Sabyasachi, Patra, Jayanta Kumar, Malik, Jai, Mandal, Sudip Kumar, Kilpatrick, Kaitlyn L., Das, Gitishree, Kerry, Rout George, Fimognari, Carmela, Bishayee, Anupam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551136/
https://www.ncbi.nlm.nih.gov/pubmed/32961827
http://dx.doi.org/10.3390/md18090476
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author Mondal, Arijit
Bose, Sankhadip
Banerjee, Sabyasachi
Patra, Jayanta Kumar
Malik, Jai
Mandal, Sudip Kumar
Kilpatrick, Kaitlyn L.
Das, Gitishree
Kerry, Rout George
Fimognari, Carmela
Bishayee, Anupam
author_facet Mondal, Arijit
Bose, Sankhadip
Banerjee, Sabyasachi
Patra, Jayanta Kumar
Malik, Jai
Mandal, Sudip Kumar
Kilpatrick, Kaitlyn L.
Das, Gitishree
Kerry, Rout George
Fimognari, Carmela
Bishayee, Anupam
author_sort Mondal, Arijit
collection PubMed
description Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.
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spelling pubmed-75511362020-10-16 Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs Mondal, Arijit Bose, Sankhadip Banerjee, Sabyasachi Patra, Jayanta Kumar Malik, Jai Mandal, Sudip Kumar Kilpatrick, Kaitlyn L. Das, Gitishree Kerry, Rout George Fimognari, Carmela Bishayee, Anupam Mar Drugs Review Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented. MDPI 2020-09-19 /pmc/articles/PMC7551136/ /pubmed/32961827 http://dx.doi.org/10.3390/md18090476 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mondal, Arijit
Bose, Sankhadip
Banerjee, Sabyasachi
Patra, Jayanta Kumar
Malik, Jai
Mandal, Sudip Kumar
Kilpatrick, Kaitlyn L.
Das, Gitishree
Kerry, Rout George
Fimognari, Carmela
Bishayee, Anupam
Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
title Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
title_full Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
title_fullStr Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
title_full_unstemmed Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
title_short Marine Cyanobacteria and Microalgae Metabolites—A Rich Source of Potential Anticancer Drugs
title_sort marine cyanobacteria and microalgae metabolites—a rich source of potential anticancer drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551136/
https://www.ncbi.nlm.nih.gov/pubmed/32961827
http://dx.doi.org/10.3390/md18090476
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