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Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients
HSCT (hematopoietic stem cell transplantation) is a widely applied method of treatment of pediatric patients with leukemia and other bone marrow-associated disorders. Metabolic disturbances can appear as procedure side effects. This study aimed to report incidence of lipid and thyroid disorders and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551147/ https://www.ncbi.nlm.nih.gov/pubmed/32825002 http://dx.doi.org/10.3390/nu12092500 |
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author | Bis, Gabriela Szlasa, Wojciech Sondaj, Katarzyna Zendran, Iga Mielcarek-Siedziuk, Monika Barg, Ewa |
author_facet | Bis, Gabriela Szlasa, Wojciech Sondaj, Katarzyna Zendran, Iga Mielcarek-Siedziuk, Monika Barg, Ewa |
author_sort | Bis, Gabriela |
collection | PubMed |
description | HSCT (hematopoietic stem cell transplantation) is a widely applied method of treatment of pediatric patients with leukemia and other bone marrow-associated disorders. Metabolic disturbances can appear as procedure side effects. This study aimed to report incidence of lipid and thyroid disorders and time of their onset in pediatric patients after HSCT. There were 198 pediatric patients (123 males) aged 0.5–20 years who were subjected to HSCT. Patients were mostly diagnosed with Acute Leukemia (n = 190). The analysis of lipids, thyroid hormones, and thyroid antibodies levels comprised one month before the HSCT to last follow up visit between 2016 and 2019 (median 3.8 ± 1.8 years after HSCT). In males, the triglycerides levels increased over two times in the course of HSCT in both patients with initially low and elevated HDL (high-density lipoprotein) levels. Most of the lipid disorders occurred in six months after HSCT. Patients treated with L-thyroxine exhibited decreased LDL (low-density lipoprotein) levels. HDL remained at a lower level in males. Thyroid hormone abnormalities were evenly distributed in time until 4 years after HSCT. Patients require long term follow up including lipid metabolism and thyroid function analysis. HSCT survivors demand introduction of polyunsaturated fatty acids into the diet to reduce risk of developing the lipid complications. |
format | Online Article Text |
id | pubmed-7551147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75511472020-10-16 Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients Bis, Gabriela Szlasa, Wojciech Sondaj, Katarzyna Zendran, Iga Mielcarek-Siedziuk, Monika Barg, Ewa Nutrients Article HSCT (hematopoietic stem cell transplantation) is a widely applied method of treatment of pediatric patients with leukemia and other bone marrow-associated disorders. Metabolic disturbances can appear as procedure side effects. This study aimed to report incidence of lipid and thyroid disorders and time of their onset in pediatric patients after HSCT. There were 198 pediatric patients (123 males) aged 0.5–20 years who were subjected to HSCT. Patients were mostly diagnosed with Acute Leukemia (n = 190). The analysis of lipids, thyroid hormones, and thyroid antibodies levels comprised one month before the HSCT to last follow up visit between 2016 and 2019 (median 3.8 ± 1.8 years after HSCT). In males, the triglycerides levels increased over two times in the course of HSCT in both patients with initially low and elevated HDL (high-density lipoprotein) levels. Most of the lipid disorders occurred in six months after HSCT. Patients treated with L-thyroxine exhibited decreased LDL (low-density lipoprotein) levels. HDL remained at a lower level in males. Thyroid hormone abnormalities were evenly distributed in time until 4 years after HSCT. Patients require long term follow up including lipid metabolism and thyroid function analysis. HSCT survivors demand introduction of polyunsaturated fatty acids into the diet to reduce risk of developing the lipid complications. MDPI 2020-08-19 /pmc/articles/PMC7551147/ /pubmed/32825002 http://dx.doi.org/10.3390/nu12092500 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bis, Gabriela Szlasa, Wojciech Sondaj, Katarzyna Zendran, Iga Mielcarek-Siedziuk, Monika Barg, Ewa Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients |
title | Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients |
title_full | Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients |
title_fullStr | Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients |
title_full_unstemmed | Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients |
title_short | Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients |
title_sort | lipid complications after hematopoietic stem cell transplantation (hsct) in pediatric patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551147/ https://www.ncbi.nlm.nih.gov/pubmed/32825002 http://dx.doi.org/10.3390/nu12092500 |
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