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Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago

Globally, a quarter of the population is infected with tuberculosis (TB), caused by Mycobacterium tuberculosis. About 5–10% of latent TB infections (LTBI) progress to active disease during the lifetime. Prevention of TB and treating LTBI is a critical component of the World Health Organization’s (WH...

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Autores principales: Chattu, Vijay Kumar, Sakhamuri, Sateesh, Motilal, Shastri, Pounder, Liam J., Persad, Vasishma Kanita, Pierre, Neelmani, Persad, Shivannie, Pooran, Nikesha, Pottinger, Akua Mosi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551204/
https://www.ncbi.nlm.nih.gov/pubmed/32727008
http://dx.doi.org/10.3390/healthcare8030236
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author Chattu, Vijay Kumar
Sakhamuri, Sateesh
Motilal, Shastri
Pounder, Liam J.
Persad, Vasishma Kanita
Pierre, Neelmani
Persad, Shivannie
Pooran, Nikesha
Pottinger, Akua Mosi
author_facet Chattu, Vijay Kumar
Sakhamuri, Sateesh
Motilal, Shastri
Pounder, Liam J.
Persad, Vasishma Kanita
Pierre, Neelmani
Persad, Shivannie
Pooran, Nikesha
Pottinger, Akua Mosi
author_sort Chattu, Vijay Kumar
collection PubMed
description Globally, a quarter of the population is infected with tuberculosis (TB), caused by Mycobacterium tuberculosis. About 5–10% of latent TB infections (LTBI) progress to active disease during the lifetime. Prevention of TB and treating LTBI is a critical component of the World Health Organization’s (WHO) End TB Strategy. This study aims to examine the screening practices for prevention and treatment employed by the National Tuberculosis Program of Trinidad and Tobago in comparison to the WHO’s standard guidelines. A cross-sectional retrospective study was conducted from the TB registers (2018–2019) for persons aged 18 years and above with recorded tuberculin skin test reactions (TST). Bivariate comparisons for categorical variables were made using Chi-square or Fisher’s exact test. Binary logistic regression was used for exploring predictors of TST positivity with adjustment for demographic confounders in multivariable models. Of the total 1972 eligible entries studied, 384 (19.4%) individuals were tested positive with TST. TB contact screening (aOR 2.49; 95% CI 1.65, 3.75) and Bacillus Calmette–Guerin (BCG) vaccination status (aOR 1.66; 95% CI, 1.24 to 2.22) were associated with a positive TST reaction, whereas, preplacement screening failed to show such association when compared to those screened as suspect cases. The findings suggest that TB contact screening and positive BCG vaccination status are associated with TST positivity independent of age and gender.
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spelling pubmed-75512042020-10-16 Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago Chattu, Vijay Kumar Sakhamuri, Sateesh Motilal, Shastri Pounder, Liam J. Persad, Vasishma Kanita Pierre, Neelmani Persad, Shivannie Pooran, Nikesha Pottinger, Akua Mosi Healthcare (Basel) Article Globally, a quarter of the population is infected with tuberculosis (TB), caused by Mycobacterium tuberculosis. About 5–10% of latent TB infections (LTBI) progress to active disease during the lifetime. Prevention of TB and treating LTBI is a critical component of the World Health Organization’s (WHO) End TB Strategy. This study aims to examine the screening practices for prevention and treatment employed by the National Tuberculosis Program of Trinidad and Tobago in comparison to the WHO’s standard guidelines. A cross-sectional retrospective study was conducted from the TB registers (2018–2019) for persons aged 18 years and above with recorded tuberculin skin test reactions (TST). Bivariate comparisons for categorical variables were made using Chi-square or Fisher’s exact test. Binary logistic regression was used for exploring predictors of TST positivity with adjustment for demographic confounders in multivariable models. Of the total 1972 eligible entries studied, 384 (19.4%) individuals were tested positive with TST. TB contact screening (aOR 2.49; 95% CI 1.65, 3.75) and Bacillus Calmette–Guerin (BCG) vaccination status (aOR 1.66; 95% CI, 1.24 to 2.22) were associated with a positive TST reaction, whereas, preplacement screening failed to show such association when compared to those screened as suspect cases. The findings suggest that TB contact screening and positive BCG vaccination status are associated with TST positivity independent of age and gender. MDPI 2020-07-27 /pmc/articles/PMC7551204/ /pubmed/32727008 http://dx.doi.org/10.3390/healthcare8030236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chattu, Vijay Kumar
Sakhamuri, Sateesh
Motilal, Shastri
Pounder, Liam J.
Persad, Vasishma Kanita
Pierre, Neelmani
Persad, Shivannie
Pooran, Nikesha
Pottinger, Akua Mosi
Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago
title Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago
title_full Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago
title_fullStr Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago
title_full_unstemmed Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago
title_short Tuberculosis Skin Test Screening in the National Tuberculosis Program of Trinidad and Tobago
title_sort tuberculosis skin test screening in the national tuberculosis program of trinidad and tobago
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551204/
https://www.ncbi.nlm.nih.gov/pubmed/32727008
http://dx.doi.org/10.3390/healthcare8030236
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