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Checkpoint kinase-1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair

Leukemia, a malignant hematological disease, has poor therapeutic outcomes due to chemotherapeutic resistance. Increasing evidence has confirmed that the elevated capacity for DNA damage repair in cancer cells is a major mechanism of acquired chemotherapeutic resistance. Thus, combining chemotherapy...

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Detalles Bibliográficos
Autores principales:	Fan, Zhuoyi, Luo, Huacheng, Zhou, Jie, Wang, Fangce, Zhang, Wenjun, Wang, Jian, Li, Shuo, Lai, Qian, Xu, Yueshuang, Wang, Guangming, Liang, Aibin, Xu, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551253/ https://www.ncbi.nlm.nih.gov/pubmed/32901871 http://dx.doi.org/10.3892/or.2020.7757

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