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Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?

Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GD...

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Autores principales: Słupecka-Ziemilska, Monika, Wychowański, Piotr, Puzianowska-Kuznicka, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551316/
https://www.ncbi.nlm.nih.gov/pubmed/32933073
http://dx.doi.org/10.3390/nu12092792
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author Słupecka-Ziemilska, Monika
Wychowański, Piotr
Puzianowska-Kuznicka, Monika
author_facet Słupecka-Ziemilska, Monika
Wychowański, Piotr
Puzianowska-Kuznicka, Monika
author_sort Słupecka-Ziemilska, Monika
collection PubMed
description Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GDM during different stages of development, paying special attention to the differences in sensitivity of offspring to maternal hyperglycemia as a result of sex-related factors. We also aim to answer the following question: If these epigenetic changes are constant throughout the lifetime of the offspring, how do they present phenotypically?
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spelling pubmed-75513162020-10-16 Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences? Słupecka-Ziemilska, Monika Wychowański, Piotr Puzianowska-Kuznicka, Monika Nutrients Review Gestational diabetes mellitus (GDM) is the most common pregnancy complication worldwide and may result in short-term and long-term consequences for offspring. The present review highlights evidence of epigenetic programming, mostly from human studies, which occurs in offspring exposed to maternal GDM during different stages of development, paying special attention to the differences in sensitivity of offspring to maternal hyperglycemia as a result of sex-related factors. We also aim to answer the following question: If these epigenetic changes are constant throughout the lifetime of the offspring, how do they present phenotypically? MDPI 2020-09-11 /pmc/articles/PMC7551316/ /pubmed/32933073 http://dx.doi.org/10.3390/nu12092792 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Słupecka-Ziemilska, Monika
Wychowański, Piotr
Puzianowska-Kuznicka, Monika
Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?
title Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?
title_full Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?
title_fullStr Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?
title_full_unstemmed Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?
title_short Gestational Diabetes Mellitus Affects Offspring’s Epigenome. Is There a Way to Reduce the Negative Consequences?
title_sort gestational diabetes mellitus affects offspring’s epigenome. is there a way to reduce the negative consequences?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551316/
https://www.ncbi.nlm.nih.gov/pubmed/32933073
http://dx.doi.org/10.3390/nu12092792
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