Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts

Tessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern Argentina for fungal infections treatment. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU),...

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Detalles Bibliográficos
Autores principales: Soberón, José R., Sgariglia, Melina A., Carabajal Torrez, José A., Aguilar, Franco A., Pero, Edgardo J.I., Sampietro, Diego A., Fernández de Luco, Julia, Labadie, Guillermo R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551329/
https://www.ncbi.nlm.nih.gov/pubmed/33083621
http://dx.doi.org/10.1016/j.heliyon.2020.e05174
Descripción
Sumario:Tessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern Argentina for fungal infections treatment. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU), against Candida albicans strains. Two antifungal flavanones were identified as naringenin (NAR) and pinocembrin (PIN). These compounds could individually inhibit the growth of C. albicans strains. Combinations of NAR and PIN with FLU were synergistic against the FLU resistant and sensitive C. albicans strains. Genotoxic and cytotoxic evaluations were also performed. NAR, PIN and their combinations with FLU did not have a genotoxic effect on Bacillus subtilis rec strains. Finally, these compounds did not show cytotoxicity at concentrations below 80 μg/mL.

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