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Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atheroscler...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551393/ https://www.ncbi.nlm.nih.gov/pubmed/32825165 http://dx.doi.org/10.3390/nu12092509 |
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author | Cassano, Velia Crescibene, Daniele Hribal, Marta Letizia Pelaia, Corrado Armentaro, Giuseppe Magurno, Marcello Toscani, Alfredo Miceli, Sofia Andreozzi, Francesco Maio, Raffaele Perticone, Maria Sesti, Giorgio Perticone, Francesco Sciacqua, Angela |
author_facet | Cassano, Velia Crescibene, Daniele Hribal, Marta Letizia Pelaia, Corrado Armentaro, Giuseppe Magurno, Marcello Toscani, Alfredo Miceli, Sofia Andreozzi, Francesco Maio, Raffaele Perticone, Maria Sesti, Giorgio Perticone, Francesco Sciacqua, Angela |
author_sort | Cassano, Velia |
collection | PubMed |
description | Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atherosclerosis, and UA. The purpose of the present study was to evaluate the association between UA and AS, considering the potential role of IR. We enrolled 1114 newly diagnosed, never-treated hypertensive patients. Insulin resistance was assessed by the homeostatic model assessment (HOMA) index. Arterial stiffness was evaluated as the measurement of the carotid–femoral pulse wave velocity (PWV). The study cohort was divided into subgroups, according to increasing tertiles of UA. The mean values of UA were 5.2 ± 1.6 mg/dL in the overall population. Pulse wave velocity was linearly correlated with UA (p < 0.0001), HOMA (p < 0.0001), high sensitivity C-reactive protein (p < 0.0001), systolic blood pressure (p < 0.0001) and LDL cholesterol (p = 0.005). Uric acid was the strongest predictor of PWV and was associated with the highest risk for increased AS. The interaction analysis showed that the joint effect of increased UA and HOMA was significantly higher than that expected in the absence of interaction under the additive model, indicating that the two biomarkers synergically interacted for promoting vascular damage. Our data showed that UA interacted with IR to increase AS in a large cohort of newly diagnosed, never-treated hypertensive patients. |
format | Online Article Text |
id | pubmed-7551393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75513932020-10-14 Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance Cassano, Velia Crescibene, Daniele Hribal, Marta Letizia Pelaia, Corrado Armentaro, Giuseppe Magurno, Marcello Toscani, Alfredo Miceli, Sofia Andreozzi, Francesco Maio, Raffaele Perticone, Maria Sesti, Giorgio Perticone, Francesco Sciacqua, Angela Nutrients Article Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atherosclerosis, and UA. The purpose of the present study was to evaluate the association between UA and AS, considering the potential role of IR. We enrolled 1114 newly diagnosed, never-treated hypertensive patients. Insulin resistance was assessed by the homeostatic model assessment (HOMA) index. Arterial stiffness was evaluated as the measurement of the carotid–femoral pulse wave velocity (PWV). The study cohort was divided into subgroups, according to increasing tertiles of UA. The mean values of UA were 5.2 ± 1.6 mg/dL in the overall population. Pulse wave velocity was linearly correlated with UA (p < 0.0001), HOMA (p < 0.0001), high sensitivity C-reactive protein (p < 0.0001), systolic blood pressure (p < 0.0001) and LDL cholesterol (p = 0.005). Uric acid was the strongest predictor of PWV and was associated with the highest risk for increased AS. The interaction analysis showed that the joint effect of increased UA and HOMA was significantly higher than that expected in the absence of interaction under the additive model, indicating that the two biomarkers synergically interacted for promoting vascular damage. Our data showed that UA interacted with IR to increase AS in a large cohort of newly diagnosed, never-treated hypertensive patients. MDPI 2020-08-19 /pmc/articles/PMC7551393/ /pubmed/32825165 http://dx.doi.org/10.3390/nu12092509 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cassano, Velia Crescibene, Daniele Hribal, Marta Letizia Pelaia, Corrado Armentaro, Giuseppe Magurno, Marcello Toscani, Alfredo Miceli, Sofia Andreozzi, Francesco Maio, Raffaele Perticone, Maria Sesti, Giorgio Perticone, Francesco Sciacqua, Angela Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance |
title | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance |
title_full | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance |
title_fullStr | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance |
title_full_unstemmed | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance |
title_short | Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance |
title_sort | uric acid and vascular damage in essential hypertension: role of insulin resistance |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551393/ https://www.ncbi.nlm.nih.gov/pubmed/32825165 http://dx.doi.org/10.3390/nu12092509 |
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