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Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance

Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atheroscler...

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Autores principales: Cassano, Velia, Crescibene, Daniele, Hribal, Marta Letizia, Pelaia, Corrado, Armentaro, Giuseppe, Magurno, Marcello, Toscani, Alfredo, Miceli, Sofia, Andreozzi, Francesco, Maio, Raffaele, Perticone, Maria, Sesti, Giorgio, Perticone, Francesco, Sciacqua, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551393/
https://www.ncbi.nlm.nih.gov/pubmed/32825165
http://dx.doi.org/10.3390/nu12092509
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author Cassano, Velia
Crescibene, Daniele
Hribal, Marta Letizia
Pelaia, Corrado
Armentaro, Giuseppe
Magurno, Marcello
Toscani, Alfredo
Miceli, Sofia
Andreozzi, Francesco
Maio, Raffaele
Perticone, Maria
Sesti, Giorgio
Perticone, Francesco
Sciacqua, Angela
author_facet Cassano, Velia
Crescibene, Daniele
Hribal, Marta Letizia
Pelaia, Corrado
Armentaro, Giuseppe
Magurno, Marcello
Toscani, Alfredo
Miceli, Sofia
Andreozzi, Francesco
Maio, Raffaele
Perticone, Maria
Sesti, Giorgio
Perticone, Francesco
Sciacqua, Angela
author_sort Cassano, Velia
collection PubMed
description Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atherosclerosis, and UA. The purpose of the present study was to evaluate the association between UA and AS, considering the potential role of IR. We enrolled 1114 newly diagnosed, never-treated hypertensive patients. Insulin resistance was assessed by the homeostatic model assessment (HOMA) index. Arterial stiffness was evaluated as the measurement of the carotid–femoral pulse wave velocity (PWV). The study cohort was divided into subgroups, according to increasing tertiles of UA. The mean values of UA were 5.2 ± 1.6 mg/dL in the overall population. Pulse wave velocity was linearly correlated with UA (p < 0.0001), HOMA (p < 0.0001), high sensitivity C-reactive protein (p < 0.0001), systolic blood pressure (p < 0.0001) and LDL cholesterol (p = 0.005). Uric acid was the strongest predictor of PWV and was associated with the highest risk for increased AS. The interaction analysis showed that the joint effect of increased UA and HOMA was significantly higher than that expected in the absence of interaction under the additive model, indicating that the two biomarkers synergically interacted for promoting vascular damage. Our data showed that UA interacted with IR to increase AS in a large cohort of newly diagnosed, never-treated hypertensive patients.
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spelling pubmed-75513932020-10-14 Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance Cassano, Velia Crescibene, Daniele Hribal, Marta Letizia Pelaia, Corrado Armentaro, Giuseppe Magurno, Marcello Toscani, Alfredo Miceli, Sofia Andreozzi, Francesco Maio, Raffaele Perticone, Maria Sesti, Giorgio Perticone, Francesco Sciacqua, Angela Nutrients Article Increased levels of uric acid (UA) have been shown to be correlated with many clinical conditions. Uric acid may adversely affect the insulin signalling pathway inducing insulin resistance (IR). Several studies report the association between arterial stiffness (AS), an early indicator of atherosclerosis, and UA. The purpose of the present study was to evaluate the association between UA and AS, considering the potential role of IR. We enrolled 1114 newly diagnosed, never-treated hypertensive patients. Insulin resistance was assessed by the homeostatic model assessment (HOMA) index. Arterial stiffness was evaluated as the measurement of the carotid–femoral pulse wave velocity (PWV). The study cohort was divided into subgroups, according to increasing tertiles of UA. The mean values of UA were 5.2 ± 1.6 mg/dL in the overall population. Pulse wave velocity was linearly correlated with UA (p < 0.0001), HOMA (p < 0.0001), high sensitivity C-reactive protein (p < 0.0001), systolic blood pressure (p < 0.0001) and LDL cholesterol (p = 0.005). Uric acid was the strongest predictor of PWV and was associated with the highest risk for increased AS. The interaction analysis showed that the joint effect of increased UA and HOMA was significantly higher than that expected in the absence of interaction under the additive model, indicating that the two biomarkers synergically interacted for promoting vascular damage. Our data showed that UA interacted with IR to increase AS in a large cohort of newly diagnosed, never-treated hypertensive patients. MDPI 2020-08-19 /pmc/articles/PMC7551393/ /pubmed/32825165 http://dx.doi.org/10.3390/nu12092509 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cassano, Velia
Crescibene, Daniele
Hribal, Marta Letizia
Pelaia, Corrado
Armentaro, Giuseppe
Magurno, Marcello
Toscani, Alfredo
Miceli, Sofia
Andreozzi, Francesco
Maio, Raffaele
Perticone, Maria
Sesti, Giorgio
Perticone, Francesco
Sciacqua, Angela
Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
title Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
title_full Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
title_fullStr Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
title_full_unstemmed Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
title_short Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance
title_sort uric acid and vascular damage in essential hypertension: role of insulin resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551393/
https://www.ncbi.nlm.nih.gov/pubmed/32825165
http://dx.doi.org/10.3390/nu12092509
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