Cargando…

TGR5 Signaling in Hepatic Metabolic Health

TGR5 is a G protein-coupled bile acid receptor that is increasingly recognized as a key regulator of glucose homeostasis. While the role of TGR5 signaling in immune cells, adipocytes and enteroendocrine L cells in metabolic regulation has been well described and extensively reviewed, the impact of T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holter, Marlena M., Chirikjian, Margot K., Govani, Viraj N., Cummings, Bethany P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551395/ https://www.ncbi.nlm.nih.gov/pubmed/32859104 http://dx.doi.org/10.3390/nu12092598

Ejemplares similares

Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice
por: Holter, Marlena M., et al.
Publicado: (2020)

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion
por: Holter, Marlena M., et al.
Publicado: (2022)

TGR5, Not Only a Metabolic Regulator
por: Guo, Cong, et al.
Publicado: (2016)

TGR5: A Novel Target for Weight Maintenance and Glucose Metabolism
por: Chen, Xiaosong, et al.
Publicado: (2011)

Multigenerational impacts of bile exposure are mediated by TGR5 signaling pathways
por: Baptissart, Marine, et al.
Publicado: (2018)

The Bile Acid Membrane Receptor TGR5 in Cancer: Friend or Foe?
por: Qi, Youchao, et al.
Publicado: (2022)

TGR5 expression in normal kidney and renal neoplasms
por: Zhao, Chaohui Lisa, et al.
Publicado: (2018)

TGR5 regulates portal perfusion pressure of the liver
por: Ghallab, Ahmed
Publicado: (2019)

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
por: Jadhav, Kavita, et al.
Publicado: (2018)

TGR5 Expression Is Associated with Changes in the Heart and Urinary Bladder of Rats with Metabolic Syndrome
por: Hsu, Chia-Chen, et al.
Publicado: (2021)

Tgr5(−/−) mice are protected from ethanol-induced metabolic alterations through enhanced leptin and Fgf21 signaling
por: Pokhrel, Sabita, et al.
Publicado: (2023)

TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue
por: Velazquez-Villegas, Laura A., et al.
Publicado: (2018)

The Gut Microbiota as a Therapeutic Target in IBD and Metabolic Disease: A Role for the Bile Acid Receptors FXR and TGR5
por: Baars, Annemarie, et al.
Publicado: (2015)

The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic syndrome
por: Stepanov, Vanesa, et al.
Publicado: (2012)

Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice
por: Finn, Patricia D., et al.
Publicado: (2019)

Central anorexigenic actions of bile acids are mediated by TGR5
por: Perino, Alessia, et al.
Publicado: (2021)

Identification of the Role of TGR5 in the Regulation of Leydig Cell Homeostasis
por: Holota, Hélène, et al.
Publicado: (2022)

Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the β-catenin destruction complex
por: Rao, Jianhua, et al.
Publicado: (2020)

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5
por: Trammell, Samuel A. J., et al.
Publicado: (2020)

6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
por: Makki, Kassem, et al.
Publicado: (2023)

MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms
por: Liang, Jiani, et al.
Publicado: (2022)

Investigation of triamterene as an inhibitor of the TGR5 receptor: identification in cells and animals
por: Li, Yingxiao, et al.
Publicado: (2017)

TGR5 agonists induce peripheral and central hypersensitivity to bladder distension
por: Caldwell, Ashlee, et al.
Publicado: (2022)

Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling
por: Hu, Jianping, et al.
Publicado: (2022)

The role of FXR and TGR5 in reversing and preventing progression of Western diet–induced hepatic steatosis, inflammation, and fibrosis in mice
por: Wang, Xiaoxin X., et al.
Publicado: (2022)

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
por: Hov, Johannes R., et al.
Publicado: (2010)

Corrigendum to: Deficiency of TGR5 exacerbates immune-mediated cholestatic hepatic injury by stabilizing the β-catenin destruction complex
por: Rao, Jianhua, et al.
Publicado: (2021)

Crosstalk between FXR and TGR5 controls glucagon-like peptide 1 secretion to maintain glycemic homeostasis
por: Kim, Hyeonhui, et al.
Publicado: (2018)

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
por: Harach, Taoufiq, et al.
Publicado: (2012)

FXR/TGR5 mediates inflammasome activation and host resistance to bacterial infection
por: Kang, Ju-Hee, et al.
Publicado: (2021)

Reversal of alopecia areata, osteoporosis follow treatment with activation of Tgr5 in mice
por: Zhou, Xiaohui, et al.
Publicado: (2021)

The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate
por: Svensson, Per-Arne, et al.
Publicado: (2013)

Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects
por: Chaudhari, Snehal N., et al.
Publicado: (2020)

TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
por: Yoneno, Kazuaki, et al.
Publicado: (2013)

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver
por: Klindt, Caroline, et al.
Publicado: (2019)

Paeoniflorin Improved Constipation in the Loperamide-Induced Rat Model via TGR5/TRPA1 Signaling-Mediated 5-Hydroxytryptamine Secretion
por: Zhan, Yu, et al.
Publicado: (2021)

Muscle-specific TGR5 overexpression improves glucose clearance in glucose-intolerant mice
por: Sasaki, Takashi, et al.
Publicado: (2020)

Role of the bile acid receptor TGR5 (Gpbar-1) in liver damage and regeneration
por: Keitel, Verena, et al.
Publicado: (2014)

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists
por: Miyata, Sachiho, et al.
Publicado: (2021)

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction
por: Leonhardt, Julia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_0kp63dsr06ngt5q0c24m3q606u