Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression. Labile heme and Hx levels are inversely correlated in the plasma of patients with prostate cancer (PCa). Further, low expression of Hx in PCa biopsi...

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Detalles Bibliográficos
Autores principales: Canesin, Giacomo, Di Ruscio, Annalisa, Li, Mailin, Ummarino, Simone, Hedblom, Andreas, Choudhury, Reeham, Krzyzanowska, Agnieszka, Csizmadia, Eva, Palominos, Macarena, Stiehm, Anna, Ebralidze, Alexander, Chen, Shao-Yong, Bassal, Mahmoud A., Zhao, Ping, Tolosano, Emanuela, Hurley, Laurence, Bjartell, Anders, Tenen, Daniel G., Wegiel, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551404/
https://www.ncbi.nlm.nih.gov/pubmed/32966797
http://dx.doi.org/10.1016/j.celrep.2020.108181

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