Investigating the Impact of Sample Preparation on Mass Spectrometry-Based Drug-To-Antibody Ratio Determination for Cysteine- and Lysine-Linked Antibody–Drug Conjugates

Antibody–drug conjugates (ADCs) are heterogeneous biotherapeutics and differ vastly in their physicochemical properties depending on their design. The number of small drug molecules covalently attached to each antibody molecule is commonly referred to as the drug-to-antibody ratio (DAR). Established...

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Detalles Bibliográficos
Autores principales: Källsten, Malin, Hartmann, Rafael, Kovac, Lucia, Lehmann, Fredrik, Lind, Sara Bergström, Bergquist, Jonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551423/
https://www.ncbi.nlm.nih.gov/pubmed/32911603
http://dx.doi.org/10.3390/antib9030046

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