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The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study

Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determin...

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Autores principales: Hakeem, Sarah, Mendonca, Nuno, Aspray, Terry, Kingston, Andrew, Ruiz-Martin, Carmen, Jagger, Carol, Mathers, John C., Duncan, Rachel, Hill, Tom R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551468/
https://www.ncbi.nlm.nih.gov/pubmed/32916847
http://dx.doi.org/10.3390/nu12092742
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author Hakeem, Sarah
Mendonca, Nuno
Aspray, Terry
Kingston, Andrew
Ruiz-Martin, Carmen
Jagger, Carol
Mathers, John C.
Duncan, Rachel
Hill, Tom R.
author_facet Hakeem, Sarah
Mendonca, Nuno
Aspray, Terry
Kingston, Andrew
Ruiz-Martin, Carmen
Jagger, Carol
Mathers, John C.
Duncan, Rachel
Hill, Tom R.
author_sort Hakeem, Sarah
collection PubMed
description Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults.
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spelling pubmed-75514682020-10-14 The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study Hakeem, Sarah Mendonca, Nuno Aspray, Terry Kingston, Andrew Ruiz-Martin, Carmen Jagger, Carol Mathers, John C. Duncan, Rachel Hill, Tom R. Nutrients Article Background: Low vitamin D status is common in very old adults which may have adverse consequences for muscle function, a major predictor of disability. Aims: To explore the association between 25-hydroxyvitamin D [25(OH)D] concentrations and disability trajectories in very old adults and to determine whether there is an ‘adequate’ 25(OH)D concentration which might protect against a faster disability trajectory. Methodology: A total of 775 participants from the Newcastle 85+ Study for who 25(OH)D concentration at baseline was available. Serum 25(OH)D concentrations of <25 nmol/L, 25–50 nmol/L and >50 nmol/L were used as cut-offs to define low, moderate and high vitamin D status, respectively. Disability was defined as difficulty in performing 17 activities of daily living, at baseline, after 18, 36 and 60 months. Results: A three-trajectory model was derived (low-to-mild, mild-to-moderate and moderate-to-severe). In partially adjusted models, participants with 25(OH)D concentrations <25 nmol/L were more likely to have moderate and severe disability trajectories, even after adjusting for sex, living in an institution, season, cognitive status, BMI and vitamin D supplement use. However, this association disappeared after further adjustment for physical activity. Conclusions: Vitamin D status does not appear to influence the trajectories of disability in very old adults. MDPI 2020-09-09 /pmc/articles/PMC7551468/ /pubmed/32916847 http://dx.doi.org/10.3390/nu12092742 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hakeem, Sarah
Mendonca, Nuno
Aspray, Terry
Kingston, Andrew
Ruiz-Martin, Carmen
Jagger, Carol
Mathers, John C.
Duncan, Rachel
Hill, Tom R.
The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
title The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
title_full The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
title_fullStr The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
title_full_unstemmed The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
title_short The Association between 25-Hydroxyvitamin D Concentration and Disability Trajectories in Very Old Adults: The Newcastle 85+ Study
title_sort association between 25-hydroxyvitamin d concentration and disability trajectories in very old adults: the newcastle 85+ study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551468/
https://www.ncbi.nlm.nih.gov/pubmed/32916847
http://dx.doi.org/10.3390/nu12092742
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