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A Perspective on Enzyme Inhibitors from Marine Organisms
Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabo...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551548/ https://www.ncbi.nlm.nih.gov/pubmed/32824888 http://dx.doi.org/10.3390/md18090431 |
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author | Tischler, Dirk |
author_facet | Tischler, Dirk |
author_sort | Tischler, Dirk |
collection | PubMed |
description | Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments. This is, and will be, a promising source for candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques were introduced into the field, and it has become easier to actually prospect for natural products, such as enzyme inhibitors. These novel compounds then need to be characterized and evaluated in comparison to well-known representatives. A number of current research projects target the exploitation of marine organisms and thus the corresponding diversity of metabolites. These are often encountered as potential drugs or biological active compounds. Among these, the class of enzyme inhibitors is an important group of compounds. There is room for new discoveries, and some more recent discoveries are highlighted herein. |
format | Online Article Text |
id | pubmed-7551548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75515482020-10-14 A Perspective on Enzyme Inhibitors from Marine Organisms Tischler, Dirk Mar Drugs Editorial Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments. This is, and will be, a promising source for candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques were introduced into the field, and it has become easier to actually prospect for natural products, such as enzyme inhibitors. These novel compounds then need to be characterized and evaluated in comparison to well-known representatives. A number of current research projects target the exploitation of marine organisms and thus the corresponding diversity of metabolites. These are often encountered as potential drugs or biological active compounds. Among these, the class of enzyme inhibitors is an important group of compounds. There is room for new discoveries, and some more recent discoveries are highlighted herein. MDPI 2020-08-19 /pmc/articles/PMC7551548/ /pubmed/32824888 http://dx.doi.org/10.3390/md18090431 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Tischler, Dirk A Perspective on Enzyme Inhibitors from Marine Organisms |
title | A Perspective on Enzyme Inhibitors from Marine Organisms |
title_full | A Perspective on Enzyme Inhibitors from Marine Organisms |
title_fullStr | A Perspective on Enzyme Inhibitors from Marine Organisms |
title_full_unstemmed | A Perspective on Enzyme Inhibitors from Marine Organisms |
title_short | A Perspective on Enzyme Inhibitors from Marine Organisms |
title_sort | perspective on enzyme inhibitors from marine organisms |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551548/ https://www.ncbi.nlm.nih.gov/pubmed/32824888 http://dx.doi.org/10.3390/md18090431 |
work_keys_str_mv | AT tischlerdirk aperspectiveonenzymeinhibitorsfrommarineorganisms AT tischlerdirk perspectiveonenzymeinhibitorsfrommarineorganisms |