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A Perspective on Enzyme Inhibitors from Marine Organisms

Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabo...

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Autor principal: Tischler, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551548/
https://www.ncbi.nlm.nih.gov/pubmed/32824888
http://dx.doi.org/10.3390/md18090431
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author Tischler, Dirk
author_facet Tischler, Dirk
author_sort Tischler, Dirk
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description Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments. This is, and will be, a promising source for candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques were introduced into the field, and it has become easier to actually prospect for natural products, such as enzyme inhibitors. These novel compounds then need to be characterized and evaluated in comparison to well-known representatives. A number of current research projects target the exploitation of marine organisms and thus the corresponding diversity of metabolites. These are often encountered as potential drugs or biological active compounds. Among these, the class of enzyme inhibitors is an important group of compounds. There is room for new discoveries, and some more recent discoveries are highlighted herein.
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spelling pubmed-75515482020-10-14 A Perspective on Enzyme Inhibitors from Marine Organisms Tischler, Dirk Mar Drugs Editorial Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments. This is, and will be, a promising source for candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques were introduced into the field, and it has become easier to actually prospect for natural products, such as enzyme inhibitors. These novel compounds then need to be characterized and evaluated in comparison to well-known representatives. A number of current research projects target the exploitation of marine organisms and thus the corresponding diversity of metabolites. These are often encountered as potential drugs or biological active compounds. Among these, the class of enzyme inhibitors is an important group of compounds. There is room for new discoveries, and some more recent discoveries are highlighted herein. MDPI 2020-08-19 /pmc/articles/PMC7551548/ /pubmed/32824888 http://dx.doi.org/10.3390/md18090431 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Tischler, Dirk
A Perspective on Enzyme Inhibitors from Marine Organisms
title A Perspective on Enzyme Inhibitors from Marine Organisms
title_full A Perspective on Enzyme Inhibitors from Marine Organisms
title_fullStr A Perspective on Enzyme Inhibitors from Marine Organisms
title_full_unstemmed A Perspective on Enzyme Inhibitors from Marine Organisms
title_short A Perspective on Enzyme Inhibitors from Marine Organisms
title_sort perspective on enzyme inhibitors from marine organisms
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551548/
https://www.ncbi.nlm.nih.gov/pubmed/32824888
http://dx.doi.org/10.3390/md18090431
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