Cargando…

The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines

Marek’s disease (MD) is an infectious malignant T-cell lymphoma proliferative disease caused by Marek’s disease virus (MDV). In recent years, the emergence of very virulent (vv) and/or very virulent plus (vv +) strains of MDV in the field has been suggested as one of the causes of vaccination failur...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Meng-ya, Li, Min, Wang, Wei-wei, Deng, Qiao-mu, Li, Qiu-hong, Gao, Yan-li, Wang, Pei-kun, Huang, Teng, Wei, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551601/
https://www.ncbi.nlm.nih.gov/pubmed/32962247
http://dx.doi.org/10.3390/v12091048
_version_ 1783593217673920512
author Shi, Meng-ya
Li, Min
Wang, Wei-wei
Deng, Qiao-mu
Li, Qiu-hong
Gao, Yan-li
Wang, Pei-kun
Huang, Teng
Wei, Ping
author_facet Shi, Meng-ya
Li, Min
Wang, Wei-wei
Deng, Qiao-mu
Li, Qiu-hong
Gao, Yan-li
Wang, Pei-kun
Huang, Teng
Wei, Ping
author_sort Shi, Meng-ya
collection PubMed
description Marek’s disease (MD) is an infectious malignant T-cell lymphoma proliferative disease caused by Marek’s disease virus (MDV). In recent years, the emergence of very virulent (vv) and/or very virulent plus (vv +) strains of MDV in the field has been suggested as one of the causes of vaccination failure. The pathogenicity of the MDV strain GX18NNM4, isolated from a clinical outbreak in a broiler breeder flock that was vaccinated with CVI988/Rispens, was investigated. In the vaccination-challenge test, GX18NNM4 was able to break through the protections provided by the vaccines CVI988 and 814. It also significantly reduced body weight gain and caused marked gross lesions and a large area of infiltration of neoplastic lymphocyte cells in the heart, liver, pancreas, etc. of the infected birds. In addition, the expressions of programmed death 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1), in the spleens and cecal tonsils (CTs) of the unvaccinated challenged birds were significantly increased compared to those in the vaccinated challenged birds, indicating that the PD-1/PD-L1 pathway is related to immune evasion mechanisms. The results showed that the GX18NNM4 strain could cause severe immunosuppression and significantly decrease the protections provided by the current commercial vaccines, thus showing GX18NNM4 to be a vv + MDV strain.
format Online
Article
Text
id pubmed-7551601
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75516012020-10-14 The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines Shi, Meng-ya Li, Min Wang, Wei-wei Deng, Qiao-mu Li, Qiu-hong Gao, Yan-li Wang, Pei-kun Huang, Teng Wei, Ping Viruses Brief Report Marek’s disease (MD) is an infectious malignant T-cell lymphoma proliferative disease caused by Marek’s disease virus (MDV). In recent years, the emergence of very virulent (vv) and/or very virulent plus (vv +) strains of MDV in the field has been suggested as one of the causes of vaccination failure. The pathogenicity of the MDV strain GX18NNM4, isolated from a clinical outbreak in a broiler breeder flock that was vaccinated with CVI988/Rispens, was investigated. In the vaccination-challenge test, GX18NNM4 was able to break through the protections provided by the vaccines CVI988 and 814. It also significantly reduced body weight gain and caused marked gross lesions and a large area of infiltration of neoplastic lymphocyte cells in the heart, liver, pancreas, etc. of the infected birds. In addition, the expressions of programmed death 1 (PD-1) and its ligand, programmed death ligand 1 (PD-L1), in the spleens and cecal tonsils (CTs) of the unvaccinated challenged birds were significantly increased compared to those in the vaccinated challenged birds, indicating that the PD-1/PD-L1 pathway is related to immune evasion mechanisms. The results showed that the GX18NNM4 strain could cause severe immunosuppression and significantly decrease the protections provided by the current commercial vaccines, thus showing GX18NNM4 to be a vv + MDV strain. MDPI 2020-09-20 /pmc/articles/PMC7551601/ /pubmed/32962247 http://dx.doi.org/10.3390/v12091048 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Shi, Meng-ya
Li, Min
Wang, Wei-wei
Deng, Qiao-mu
Li, Qiu-hong
Gao, Yan-li
Wang, Pei-kun
Huang, Teng
Wei, Ping
The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
title The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
title_full The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
title_fullStr The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
title_full_unstemmed The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
title_short The Emergence of a vv + MDV Can Break through the Protections Provided by the Current Vaccines
title_sort emergence of a vv + mdv can break through the protections provided by the current vaccines
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551601/
https://www.ncbi.nlm.nih.gov/pubmed/32962247
http://dx.doi.org/10.3390/v12091048
work_keys_str_mv AT shimengya theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT limin theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT wangweiwei theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT dengqiaomu theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT liqiuhong theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT gaoyanli theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT wangpeikun theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT huangteng theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT weiping theemergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT shimengya emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT limin emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT wangweiwei emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT dengqiaomu emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT liqiuhong emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT gaoyanli emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT wangpeikun emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT huangteng emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines
AT weiping emergenceofavvmdvcanbreakthroughtheprotectionsprovidedbythecurrentvaccines