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Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction

Low serum albumin (LSA) on admission for acute myocardial infarction (AMI) is related to adverse in-hospital outcomes. However, the relationship between LSA and long-term post-AMI cardiovascular outcomes is unknown. A single-center, non-randomized, retrospective study was performed to investigate th...

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Autores principales: Yoshioka, Goro, Tanaka, Atsushi, Nishihira, Kensaku, Shibata, Yoshisato, Node, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551643/
https://www.ncbi.nlm.nih.gov/pubmed/32872477
http://dx.doi.org/10.3390/nu12092637
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author Yoshioka, Goro
Tanaka, Atsushi
Nishihira, Kensaku
Shibata, Yoshisato
Node, Koichi
author_facet Yoshioka, Goro
Tanaka, Atsushi
Nishihira, Kensaku
Shibata, Yoshisato
Node, Koichi
author_sort Yoshioka, Goro
collection PubMed
description Low serum albumin (LSA) on admission for acute myocardial infarction (AMI) is related to adverse in-hospital outcomes. However, the relationship between LSA and long-term post-AMI cardiovascular outcomes is unknown. A single-center, non-randomized, retrospective study was performed to investigate the prognostic impact of LSA at admission for AMI on cardiovascular death or newly developed HF in the remote phase after AMI. Admission serum albumin tertiles (<3.8, 3.8–4.2, ≥4.2 g/dL) were used to divide 2253 consecutive AMI from February 2008 to January 2016 patients into three groups. Primary outcome was a composite of hospitalization for HF and cardiovascular death remotely after AMI. Cox proportional hazard models were used to explore the relationship between admission LSA and primary outcome. During follow-up (median: 3.2 years), primary composite outcome occurred in 305 patients (13.5%). Primary composite outcome occurred individually for hospitalization for HF in 146 patients (6.5%) and cardiovascular death in 192 patients (8.5%). The cumulative incidence of primary composite outcome was higher in the LSA group than the other groups (log-rank test, p < 0.001). Even after adjustments for relevant clinical variables, LSA (<3.8 mg/dL) was an independent predictor of remote-phase primary composite outcome, irrespective of the clinical severity and subtype of AMI. Thus, LSA on admission for AMI was an independent predictor of newly developed HF or cardiovascular death and has a useful prognostic impact even remotely after AMI.
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spelling pubmed-75516432020-10-14 Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction Yoshioka, Goro Tanaka, Atsushi Nishihira, Kensaku Shibata, Yoshisato Node, Koichi Nutrients Article Low serum albumin (LSA) on admission for acute myocardial infarction (AMI) is related to adverse in-hospital outcomes. However, the relationship between LSA and long-term post-AMI cardiovascular outcomes is unknown. A single-center, non-randomized, retrospective study was performed to investigate the prognostic impact of LSA at admission for AMI on cardiovascular death or newly developed HF in the remote phase after AMI. Admission serum albumin tertiles (<3.8, 3.8–4.2, ≥4.2 g/dL) were used to divide 2253 consecutive AMI from February 2008 to January 2016 patients into three groups. Primary outcome was a composite of hospitalization for HF and cardiovascular death remotely after AMI. Cox proportional hazard models were used to explore the relationship between admission LSA and primary outcome. During follow-up (median: 3.2 years), primary composite outcome occurred in 305 patients (13.5%). Primary composite outcome occurred individually for hospitalization for HF in 146 patients (6.5%) and cardiovascular death in 192 patients (8.5%). The cumulative incidence of primary composite outcome was higher in the LSA group than the other groups (log-rank test, p < 0.001). Even after adjustments for relevant clinical variables, LSA (<3.8 mg/dL) was an independent predictor of remote-phase primary composite outcome, irrespective of the clinical severity and subtype of AMI. Thus, LSA on admission for AMI was an independent predictor of newly developed HF or cardiovascular death and has a useful prognostic impact even remotely after AMI. MDPI 2020-08-29 /pmc/articles/PMC7551643/ /pubmed/32872477 http://dx.doi.org/10.3390/nu12092637 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshioka, Goro
Tanaka, Atsushi
Nishihira, Kensaku
Shibata, Yoshisato
Node, Koichi
Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction
title Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction
title_full Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction
title_fullStr Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction
title_full_unstemmed Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction
title_short Prognostic Impact of Serum Albumin for Developing Heart Failure Remotely after Acute Myocardial Infarction
title_sort prognostic impact of serum albumin for developing heart failure remotely after acute myocardial infarction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551643/
https://www.ncbi.nlm.nih.gov/pubmed/32872477
http://dx.doi.org/10.3390/nu12092637
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