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Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042

Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant...

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Autores principales: Lee, Eun-Soo, Lee, Eun-Young, Yoon, Jisoo, Hong, Ahreum, Nam, Sang-Jip, Ko, Jaeyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551700/
https://www.ncbi.nlm.nih.gov/pubmed/32927886
http://dx.doi.org/10.3390/md18090463
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author Lee, Eun-Soo
Lee, Eun-Young
Yoon, Jisoo
Hong, Ahreum
Nam, Sang-Jip
Ko, Jaeyoung
author_facet Lee, Eun-Soo
Lee, Eun-Young
Yoon, Jisoo
Hong, Ahreum
Nam, Sang-Jip
Ko, Jaeyoung
author_sort Lee, Eun-Soo
collection PubMed
description Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derived Streptomyces sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression.
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spelling pubmed-75517002020-10-14 Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 Lee, Eun-Soo Lee, Eun-Young Yoon, Jisoo Hong, Ahreum Nam, Sang-Jip Ko, Jaeyoung Mar Drugs Article Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derived Streptomyces sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression. MDPI 2020-09-10 /pmc/articles/PMC7551700/ /pubmed/32927886 http://dx.doi.org/10.3390/md18090463 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Eun-Soo
Lee, Eun-Young
Yoon, Jisoo
Hong, Ahreum
Nam, Sang-Jip
Ko, Jaeyoung
Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
title Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
title_full Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
title_fullStr Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
title_full_unstemmed Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
title_short Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
title_sort sarmentosamide, an anti-aging compound from a marine-derived streptomyces sp. apmarine042
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551700/
https://www.ncbi.nlm.nih.gov/pubmed/32927886
http://dx.doi.org/10.3390/md18090463
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