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Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551700/ https://www.ncbi.nlm.nih.gov/pubmed/32927886 http://dx.doi.org/10.3390/md18090463 |
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author | Lee, Eun-Soo Lee, Eun-Young Yoon, Jisoo Hong, Ahreum Nam, Sang-Jip Ko, Jaeyoung |
author_facet | Lee, Eun-Soo Lee, Eun-Young Yoon, Jisoo Hong, Ahreum Nam, Sang-Jip Ko, Jaeyoung |
author_sort | Lee, Eun-Soo |
collection | PubMed |
description | Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derived Streptomyces sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression. |
format | Online Article Text |
id | pubmed-7551700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75517002020-10-14 Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 Lee, Eun-Soo Lee, Eun-Young Yoon, Jisoo Hong, Ahreum Nam, Sang-Jip Ko, Jaeyoung Mar Drugs Article Many bioactive materials have been isolated from marine microorganisms, including alkaloids, peptides, lipids, mycosporine-like amino acids, glycosides, and isoprenoids. Some of these compounds have great potential in the cosmetic industry due to their photo-protective, anti-aging, and anti-oxidant activities. In this study, sarmentosamide (1) was isolated from marine-derived Streptomyces sp. APmarine042, after which its capacity to decrease skin aging was examined in-vitro. Sarmentosamide (1) was found to significantly reduce UVB-induced matrix metalloproteinase-1 (MMP-1) expression in normal human dermal fibroblasts (NHDFs) by inhibiting the extracellular signal-regulated kinase (ERK) and the c-Jun N-terminal kinase (JNK) phosphorylation, which are regulatory pathways upstream of MMP-1 transcription. Additionally, we confirmed that sarmentosamide (1) decreased tumor necrosis factor-alpha (TNF-α), induced MMP-1 secretion in NHDFs, and exhibited free-radical scavenging activity, as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Therefore, our study suggests that sarmentosamide (1) could be a promising anti-aging agent that acts via the downregulation of MMP-1 expression. MDPI 2020-09-10 /pmc/articles/PMC7551700/ /pubmed/32927886 http://dx.doi.org/10.3390/md18090463 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Eun-Soo Lee, Eun-Young Yoon, Jisoo Hong, Ahreum Nam, Sang-Jip Ko, Jaeyoung Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 |
title | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 |
title_full | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 |
title_fullStr | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 |
title_full_unstemmed | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 |
title_short | Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042 |
title_sort | sarmentosamide, an anti-aging compound from a marine-derived streptomyces sp. apmarine042 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551700/ https://www.ncbi.nlm.nih.gov/pubmed/32927886 http://dx.doi.org/10.3390/md18090463 |
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