Cargando…

From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry

Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results:...

Descripción completa

Detalles Bibliográficos
Autor principal: Kanduc, Darja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551747/
https://www.ncbi.nlm.nih.gov/pubmed/32708525
http://dx.doi.org/10.3390/antib9030033
_version_ 1783593246335696896
author Kanduc, Darja
author_facet Kanduc, Darja
author_sort Kanduc, Darja
collection PubMed
description Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results: Immunoreactive epitopes present in SARS-CoV-2 were mostly composed of peptide sequences present in human proteins that—when altered, mutated, deficient or, however, improperly functioning—may associate with a wide range of disorders, from respiratory distress to multiple organ failure. Conclusions: This study represents a starting point or hint for future scientific–clinical investigations and suggests a range of possible protein targets of autoimmunity in SARS-CoV-2 infection. From an experimental perspective, the results warrant the testing of patients’ sera for autoantibodies against these protein targets. Clinically, the results warrant a stringent surveillance on the future pathologic sequelae of the current SARS-CoV-2 pandemic.
format Online
Article
Text
id pubmed-7551747
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75517472020-10-14 From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry Kanduc, Darja Antibodies (Basel) Article Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results: Immunoreactive epitopes present in SARS-CoV-2 were mostly composed of peptide sequences present in human proteins that—when altered, mutated, deficient or, however, improperly functioning—may associate with a wide range of disorders, from respiratory distress to multiple organ failure. Conclusions: This study represents a starting point or hint for future scientific–clinical investigations and suggests a range of possible protein targets of autoimmunity in SARS-CoV-2 infection. From an experimental perspective, the results warrant the testing of patients’ sera for autoantibodies against these protein targets. Clinically, the results warrant a stringent surveillance on the future pathologic sequelae of the current SARS-CoV-2 pandemic. MDPI 2020-07-16 /pmc/articles/PMC7551747/ /pubmed/32708525 http://dx.doi.org/10.3390/antib9030033 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanduc, Darja
From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
title From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
title_full From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
title_fullStr From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
title_full_unstemmed From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
title_short From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
title_sort from anti-sars-cov-2 immune responses to covid-19 via molecular mimicry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551747/
https://www.ncbi.nlm.nih.gov/pubmed/32708525
http://dx.doi.org/10.3390/antib9030033
work_keys_str_mv AT kanducdarja fromantisarscov2immuneresponsestocovid19viamolecularmimicry