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From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry
Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results:...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551747/ https://www.ncbi.nlm.nih.gov/pubmed/32708525 http://dx.doi.org/10.3390/antib9030033 |
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author | Kanduc, Darja |
author_facet | Kanduc, Darja |
author_sort | Kanduc, Darja |
collection | PubMed |
description | Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results: Immunoreactive epitopes present in SARS-CoV-2 were mostly composed of peptide sequences present in human proteins that—when altered, mutated, deficient or, however, improperly functioning—may associate with a wide range of disorders, from respiratory distress to multiple organ failure. Conclusions: This study represents a starting point or hint for future scientific–clinical investigations and suggests a range of possible protein targets of autoimmunity in SARS-CoV-2 infection. From an experimental perspective, the results warrant the testing of patients’ sera for autoantibodies against these protein targets. Clinically, the results warrant a stringent surveillance on the future pathologic sequelae of the current SARS-CoV-2 pandemic. |
format | Online Article Text |
id | pubmed-7551747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75517472020-10-14 From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry Kanduc, Darja Antibodies (Basel) Article Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results: Immunoreactive epitopes present in SARS-CoV-2 were mostly composed of peptide sequences present in human proteins that—when altered, mutated, deficient or, however, improperly functioning—may associate with a wide range of disorders, from respiratory distress to multiple organ failure. Conclusions: This study represents a starting point or hint for future scientific–clinical investigations and suggests a range of possible protein targets of autoimmunity in SARS-CoV-2 infection. From an experimental perspective, the results warrant the testing of patients’ sera for autoantibodies against these protein targets. Clinically, the results warrant a stringent surveillance on the future pathologic sequelae of the current SARS-CoV-2 pandemic. MDPI 2020-07-16 /pmc/articles/PMC7551747/ /pubmed/32708525 http://dx.doi.org/10.3390/antib9030033 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kanduc, Darja From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry |
title | From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry |
title_full | From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry |
title_fullStr | From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry |
title_full_unstemmed | From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry |
title_short | From Anti-SARS-CoV-2 Immune Responses to COVID-19 via Molecular Mimicry |
title_sort | from anti-sars-cov-2 immune responses to covid-19 via molecular mimicry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551747/ https://www.ncbi.nlm.nih.gov/pubmed/32708525 http://dx.doi.org/10.3390/antib9030033 |
work_keys_str_mv | AT kanducdarja fromantisarscov2immuneresponsestocovid19viamolecularmimicry |