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Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study
Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, norma...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551765/ https://www.ncbi.nlm.nih.gov/pubmed/32887379 http://dx.doi.org/10.3390/nu12092676 |
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author | Fuse, Sayuri Endo, Tasuki Tanaka, Riki Kuroiwa, Miyuki Ando, Akira Kume, Ayami Yamamoto, Akiko Kuribayashi, Kanna Somekawa, Shinji Takeshita, Masamichi Hashimoto, Masaki Kime, Ryotaro Kurosawa, Yuko Hamaoka, Takafumi |
author_facet | Fuse, Sayuri Endo, Tasuki Tanaka, Riki Kuroiwa, Miyuki Ando, Akira Kume, Ayami Yamamoto, Akiko Kuribayashi, Kanna Somekawa, Shinji Takeshita, Masamichi Hashimoto, Masaki Kime, Ryotaro Kurosawa, Yuko Hamaoka, Takafumi |
author_sort | Fuse, Sayuri |
collection | PubMed |
description | Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, normal to overweight subjects (Sub(healthy)) with distinct BAT characteristics. We examined the changes in BAT density (BAT-d), using near-infrared time-resolved spectroscopy, and REE/kg induced by daily CI. Forty Sub(healthy) [age, 43.8 (mean) years; BMI, 25.4 kg/m(2)] received either capsinoid (9 mg/day) or a placebo daily for 6 weeks in a double-blind design. Total hemoglobin concentration in the supraclavicular region ([total-Hb](sup)), an indicator of BAT-d, and REE/kg were measured. The changes in post-intervention [total-Hb](sup) were greater in the capsinoid group (CA-G) than in the placebo group (PL-G) [5.8 µM (+12.4%) versus 1.0 µM (+2.1%); p = 0.017]. There was a significant relationship between BAT-d and REE/kg; however, post-supplementation REE/kg was not significantly different between the two groups (p = 0.228). In the overweight subgroup, changes in REE/kg were greater in the CA-G than in the PL-G [0.6 cal/kg/min (+4.3%) versus −0.3 cal/kg/min (−2.1%); p = 0.021]. CI enhanced [total-Hb](sup), a reflection of BAT-d, showing a good correlation with REE in Sub(healthy). |
format | Online Article Text |
id | pubmed-7551765 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75517652020-10-14 Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study Fuse, Sayuri Endo, Tasuki Tanaka, Riki Kuroiwa, Miyuki Ando, Akira Kume, Ayami Yamamoto, Akiko Kuribayashi, Kanna Somekawa, Shinji Takeshita, Masamichi Hashimoto, Masaki Kime, Ryotaro Kurosawa, Yuko Hamaoka, Takafumi Nutrients Article Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, normal to overweight subjects (Sub(healthy)) with distinct BAT characteristics. We examined the changes in BAT density (BAT-d), using near-infrared time-resolved spectroscopy, and REE/kg induced by daily CI. Forty Sub(healthy) [age, 43.8 (mean) years; BMI, 25.4 kg/m(2)] received either capsinoid (9 mg/day) or a placebo daily for 6 weeks in a double-blind design. Total hemoglobin concentration in the supraclavicular region ([total-Hb](sup)), an indicator of BAT-d, and REE/kg were measured. The changes in post-intervention [total-Hb](sup) were greater in the capsinoid group (CA-G) than in the placebo group (PL-G) [5.8 µM (+12.4%) versus 1.0 µM (+2.1%); p = 0.017]. There was a significant relationship between BAT-d and REE/kg; however, post-supplementation REE/kg was not significantly different between the two groups (p = 0.228). In the overweight subgroup, changes in REE/kg were greater in the CA-G than in the PL-G [0.6 cal/kg/min (+4.3%) versus −0.3 cal/kg/min (−2.1%); p = 0.021]. CI enhanced [total-Hb](sup), a reflection of BAT-d, showing a good correlation with REE in Sub(healthy). MDPI 2020-09-02 /pmc/articles/PMC7551765/ /pubmed/32887379 http://dx.doi.org/10.3390/nu12092676 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fuse, Sayuri Endo, Tasuki Tanaka, Riki Kuroiwa, Miyuki Ando, Akira Kume, Ayami Yamamoto, Akiko Kuribayashi, Kanna Somekawa, Shinji Takeshita, Masamichi Hashimoto, Masaki Kime, Ryotaro Kurosawa, Yuko Hamaoka, Takafumi Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
title | Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
title_full | Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
title_fullStr | Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
title_full_unstemmed | Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
title_short | Effects of Capsinoid Intake on Brown Adipose Tissue Vascular Density and Resting Energy Expenditure in Healthy, Middle-Aged Adults: A Randomized, Double-Blind, Placebo-Controlled Study |
title_sort | effects of capsinoid intake on brown adipose tissue vascular density and resting energy expenditure in healthy, middle-aged adults: a randomized, double-blind, placebo-controlled study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551765/ https://www.ncbi.nlm.nih.gov/pubmed/32887379 http://dx.doi.org/10.3390/nu12092676 |
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