Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp

Exploration for specialized metabolites of Okinawan marine sponges Agelas spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5). Their structures were elucidated on the basis...

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Autores principales: Lee, Sanghoon, Tanaka, Naonobu, Takahashi, Sakura, Tsuji, Daisuke, Kim, Sang-Yong, Kojoma, Mareshige, Itoh, Kohji, Kobayashi, Jun’ichi, Kashiwada, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551770/
https://www.ncbi.nlm.nih.gov/pubmed/32872586
http://dx.doi.org/10.3390/md18090455
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author Lee, Sanghoon
Tanaka, Naonobu
Takahashi, Sakura
Tsuji, Daisuke
Kim, Sang-Yong
Kojoma, Mareshige
Itoh, Kohji
Kobayashi, Jun’ichi
Kashiwada, Yoshiki
author_facet Lee, Sanghoon
Tanaka, Naonobu
Takahashi, Sakura
Tsuji, Daisuke
Kim, Sang-Yong
Kojoma, Mareshige
Itoh, Kohji
Kobayashi, Jun’ichi
Kashiwada, Yoshiki
author_sort Lee, Sanghoon
collection PubMed
description Exploration for specialized metabolites of Okinawan marine sponges Agelas spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5). Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A (1) and B (2) were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while 3–5 were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole, or N-methylated aminoimidazole moieties.
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spelling pubmed-75517702020-10-14 Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp Lee, Sanghoon Tanaka, Naonobu Takahashi, Sakura Tsuji, Daisuke Kim, Sang-Yong Kojoma, Mareshige Itoh, Kohji Kobayashi, Jun’ichi Kashiwada, Yoshiki Mar Drugs Article Exploration for specialized metabolites of Okinawan marine sponges Agelas spp. resulted in the isolation of five new bromopyrrole alkaloids, agesasines A (1) and B (2), 9-hydroxydihydrodispacamide (3), 9-hydroxydihydrooroidin (4), and 9E-keramadine (5). Their structures were elucidated on the basis of spectroscopic analyses. Agesasines A (1) and B (2) were assigned as rare bromopyrrole alkaloids lacking an aminoimidazole moiety, while 3–5 were elucidated to be linear bromopyrrole alkaloids with either aminoimidazolone, aminoimidazole, or N-methylated aminoimidazole moieties. MDPI 2020-08-30 /pmc/articles/PMC7551770/ /pubmed/32872586 http://dx.doi.org/10.3390/md18090455 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Sanghoon
Tanaka, Naonobu
Takahashi, Sakura
Tsuji, Daisuke
Kim, Sang-Yong
Kojoma, Mareshige
Itoh, Kohji
Kobayashi, Jun’ichi
Kashiwada, Yoshiki
Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
title Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
title_full Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
title_fullStr Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
title_full_unstemmed Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
title_short Agesasines A and B, Bromopyrrole Alkaloids from Marine Sponges Agelas spp
title_sort agesasines a and b, bromopyrrole alkaloids from marine sponges agelas spp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551770/
https://www.ncbi.nlm.nih.gov/pubmed/32872586
http://dx.doi.org/10.3390/md18090455
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