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Vitamin D Deficiency and Outcome of COVID-19 Patients
Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551780/ https://www.ncbi.nlm.nih.gov/pubmed/32927735 http://dx.doi.org/10.3390/nu12092757 |
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author | Radujkovic, Aleksandar Hippchen, Theresa Tiwari-Heckler, Shilpa Dreher, Saida Boxberger, Monica Merle, Uta |
author_facet | Radujkovic, Aleksandar Hippchen, Theresa Tiwari-Heckler, Shilpa Dreher, Saida Boxberger, Monica Merle, Uta |
author_sort | Radujkovic, Aleksandar |
collection | PubMed |
description | Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2–92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79–13.42, p < 0.001 and HR 14.73, 95% CI 4.16–52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals. |
format | Online Article Text |
id | pubmed-7551780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75517802020-10-14 Vitamin D Deficiency and Outcome of COVID-19 Patients Radujkovic, Aleksandar Hippchen, Theresa Tiwari-Heckler, Shilpa Dreher, Saida Boxberger, Monica Merle, Uta Nutrients Article Infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses an enormous challenge to health care systems throughout the world. Without causal treatment, identification of modifiable prognostic factors may help to improve outcomes. To explore possible associations of vitamin D (VitD) status with disease severity and survival, we studied 185 patients diagnosed with coronavirus disease 2019 (COVID-19) and treated at our center. VitD status at first presentation was assessed retrospectively using accredited laboratory methods. VitD deficiency was defined as serum total 25-hydroxyvitamin D level < 12 ng/mL (<30 nM). Primary endpoint was severe course of disease (i.e., need for invasive mechanical ventilation and/or death, IMV/D). Within a median observation period of 66 days (range 2–92), 23 patients required IMV. A total of 28 patients had IMV/D, including 16 deaths. Ninety-three (50%) patients required hospitalization (inpatient subgroup). A total of 41 (22%) patients were VitD deficient. When adjusted for age, gender, and comorbidities, VitD deficiency was associated with higher risk of IMV/D and death (HR 6.12, 95% CI 2.79–13.42, p < 0.001 and HR 14.73, 95% CI 4.16–52.19, p < 0.001, respectively). Similar correlations were observed in the inpatient subgroup. Our study demonstrates an association between VitD deficiency and severity/mortality of COVID-19, highlighting the need for interventional studies on VitD supplementation in SARS-CoV-2 infected individuals. MDPI 2020-09-10 /pmc/articles/PMC7551780/ /pubmed/32927735 http://dx.doi.org/10.3390/nu12092757 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Radujkovic, Aleksandar Hippchen, Theresa Tiwari-Heckler, Shilpa Dreher, Saida Boxberger, Monica Merle, Uta Vitamin D Deficiency and Outcome of COVID-19 Patients |
title | Vitamin D Deficiency and Outcome of COVID-19 Patients |
title_full | Vitamin D Deficiency and Outcome of COVID-19 Patients |
title_fullStr | Vitamin D Deficiency and Outcome of COVID-19 Patients |
title_full_unstemmed | Vitamin D Deficiency and Outcome of COVID-19 Patients |
title_short | Vitamin D Deficiency and Outcome of COVID-19 Patients |
title_sort | vitamin d deficiency and outcome of covid-19 patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551780/ https://www.ncbi.nlm.nih.gov/pubmed/32927735 http://dx.doi.org/10.3390/nu12092757 |
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