Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its patho...

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Autores principales: Boyer-Diaz, Zoe, Morata, Paloma, Aristu-Zabalza, Peio, Gibert-Ramos, Albert, Bosch, Jaime, Gracia-Sancho, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551786/
https://www.ncbi.nlm.nih.gov/pubmed/32872239
http://dx.doi.org/10.3390/nu12092627
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author Boyer-Diaz, Zoe
Morata, Paloma
Aristu-Zabalza, Peio
Gibert-Ramos, Albert
Bosch, Jaime
Gracia-Sancho, Jordi
author_facet Boyer-Diaz, Zoe
Morata, Paloma
Aristu-Zabalza, Peio
Gibert-Ramos, Albert
Bosch, Jaime
Gracia-Sancho, Jordi
author_sort Boyer-Diaz, Zoe
collection PubMed
description Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data.
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spelling pubmed-75517862020-10-14 Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical Boyer-Diaz, Zoe Morata, Paloma Aristu-Zabalza, Peio Gibert-Ramos, Albert Bosch, Jaime Gracia-Sancho, Jordi Nutrients Review Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data. MDPI 2020-08-28 /pmc/articles/PMC7551786/ /pubmed/32872239 http://dx.doi.org/10.3390/nu12092627 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Boyer-Diaz, Zoe
Morata, Paloma
Aristu-Zabalza, Peio
Gibert-Ramos, Albert
Bosch, Jaime
Gracia-Sancho, Jordi
Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical
title Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical
title_full Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical
title_fullStr Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical
title_full_unstemmed Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical
title_short Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical
title_sort oxidative stress in chronic liver disease and portal hypertension: potential of dha as nutraceutical
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551786/
https://www.ncbi.nlm.nih.gov/pubmed/32872239
http://dx.doi.org/10.3390/nu12092627
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