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Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate

Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized p...

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Autores principales: Maier, Jeanette A., Pickering, Gisele, Giacomoni, Elena, Cazzaniga, Alessandra, Pellegrino, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551876/
https://www.ncbi.nlm.nih.gov/pubmed/32878232
http://dx.doi.org/10.3390/nu12092660
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author Maier, Jeanette A.
Pickering, Gisele
Giacomoni, Elena
Cazzaniga, Alessandra
Pellegrino, Paolo
author_facet Maier, Jeanette A.
Pickering, Gisele
Giacomoni, Elena
Cazzaniga, Alessandra
Pellegrino, Paolo
author_sort Maier, Jeanette A.
collection PubMed
description Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines.
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spelling pubmed-75518762020-10-14 Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate Maier, Jeanette A. Pickering, Gisele Giacomoni, Elena Cazzaniga, Alessandra Pellegrino, Paolo Nutrients Review Magnesium deficiency may occur for several reasons, such as inadequate intake or increased gastrointestinal or renal loss. A large body of literature suggests a relationship between magnesium deficiency and mild and moderate tension-type headaches and migraines. A number of double-blind randomized placebo-controlled trials have shown that magnesium is efficacious in relieving headaches and have led to the recommendation of oral magnesium for headache relief in several national and international guidelines. Among several magnesium salts available to treat magnesium deficiency, magnesium pidolate may have high bioavailability and good penetration at the intracellular level. Here, we discuss the cellular and molecular effects of magnesium deficiency in the brain and the clinical evidence supporting the use of magnesium for the treatment of headaches and migraines. MDPI 2020-08-31 /pmc/articles/PMC7551876/ /pubmed/32878232 http://dx.doi.org/10.3390/nu12092660 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Maier, Jeanette A.
Pickering, Gisele
Giacomoni, Elena
Cazzaniga, Alessandra
Pellegrino, Paolo
Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
title Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
title_full Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
title_fullStr Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
title_full_unstemmed Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
title_short Headaches and Magnesium: Mechanisms, Bioavailability, Therapeutic Efficacy and Potential Advantage of Magnesium Pidolate
title_sort headaches and magnesium: mechanisms, bioavailability, therapeutic efficacy and potential advantage of magnesium pidolate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551876/
https://www.ncbi.nlm.nih.gov/pubmed/32878232
http://dx.doi.org/10.3390/nu12092660
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