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Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life

Background: The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with risk of incident hypertension later in life. Methods: We perform...

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Autores principales: Zhou, Yunping, Wang, Tao, Yin, Xin, Sun, Yun, Seow, Wei Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551896/
https://www.ncbi.nlm.nih.gov/pubmed/32872103
http://dx.doi.org/10.3390/nu12092622
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author Zhou, Yunping
Wang, Tao
Yin, Xin
Sun, Yun
Seow, Wei Jie
author_facet Zhou, Yunping
Wang, Tao
Yin, Xin
Sun, Yun
Seow, Wei Jie
author_sort Zhou, Yunping
collection PubMed
description Background: The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with risk of incident hypertension later in life. Methods: We performed a retrospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES). Five weight change groups were categorized: stable normal, weight loss, weight gain, maximum overweight and stable obese. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between weight change and risk of hypertension in later life were estimated using Cox regression models. Results: Compared with participants who maintained normal weight, the stable obese, weight gain, maximum overweight and weight loss groups exhibited significantly higher risks of incident hypertension, with HR of 3.28 (95% CI = 2.71 to 3.96), 2.93 (95% CI = 2.62 to 3.28), 1.76 (95% CI = 1.55 to 2.00) and 1.97 (95% CI = 1.17 to 3.31), respectively. We also observed a lower risk among those in the weight loss group (HR = 0.60, 95% CI = 0.35 to 1.02) compared with those who were stable obese. Conclusions: Weight loss from early to middle adulthood was associated with lower risk of incident hypertension as compared to those who stayed obese and higher risk of incident hypertension as compared to those who maintained normal weight. Thus, maintaining normal weight throughout adulthood may be important for the primary prevention of hypertension.
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spelling pubmed-75518962020-10-14 Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life Zhou, Yunping Wang, Tao Yin, Xin Sun, Yun Seow, Wei Jie Nutrients Article Background: The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with risk of incident hypertension later in life. Methods: We performed a retrospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES). Five weight change groups were categorized: stable normal, weight loss, weight gain, maximum overweight and stable obese. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between weight change and risk of hypertension in later life were estimated using Cox regression models. Results: Compared with participants who maintained normal weight, the stable obese, weight gain, maximum overweight and weight loss groups exhibited significantly higher risks of incident hypertension, with HR of 3.28 (95% CI = 2.71 to 3.96), 2.93 (95% CI = 2.62 to 3.28), 1.76 (95% CI = 1.55 to 2.00) and 1.97 (95% CI = 1.17 to 3.31), respectively. We also observed a lower risk among those in the weight loss group (HR = 0.60, 95% CI = 0.35 to 1.02) compared with those who were stable obese. Conclusions: Weight loss from early to middle adulthood was associated with lower risk of incident hypertension as compared to those who stayed obese and higher risk of incident hypertension as compared to those who maintained normal weight. Thus, maintaining normal weight throughout adulthood may be important for the primary prevention of hypertension. MDPI 2020-08-28 /pmc/articles/PMC7551896/ /pubmed/32872103 http://dx.doi.org/10.3390/nu12092622 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Yunping
Wang, Tao
Yin, Xin
Sun, Yun
Seow, Wei Jie
Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
title Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
title_full Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
title_fullStr Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
title_full_unstemmed Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
title_short Association of Weight Loss from Early to Middle Adulthood and Incident Hypertension Risk Later in Life
title_sort association of weight loss from early to middle adulthood and incident hypertension risk later in life
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551896/
https://www.ncbi.nlm.nih.gov/pubmed/32872103
http://dx.doi.org/10.3390/nu12092622
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