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High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers
Aim: Patients on parenteral nutrition (PN) are prone to inflammation. This may aggravate an existing proinflammatory state and become a critical factor in the development of liver dysfunction (LD). Intravenous fish oil may attenuate this inflammatory state, but data on its use in adults are scarce....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551918/ https://www.ncbi.nlm.nih.gov/pubmed/32961695 http://dx.doi.org/10.3390/nu12092865 |
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author | Klek, Stanislaw Mankowska-Wierzbicka, Dorota Scislo, Lucyna Walewska, Elzbieta Pietka, Magdalena Szczepanek, Kinga |
author_facet | Klek, Stanislaw Mankowska-Wierzbicka, Dorota Scislo, Lucyna Walewska, Elzbieta Pietka, Magdalena Szczepanek, Kinga |
author_sort | Klek, Stanislaw |
collection | PubMed |
description | Aim: Patients on parenteral nutrition (PN) are prone to inflammation. This may aggravate an existing proinflammatory state and become a critical factor in the development of liver dysfunction (LD). Intravenous fish oil may attenuate this inflammatory state, but data on its use in adults are scarce. The aim of this study was to investigate the effects of adding a pure fish oil intravenous lipid emulsion (ILE) into short- and long-term PN in patients either at risk of, or with existing, inflammation. Methods: A retrospective analysis of 61 patients (32 female, 29 male, mean age 51.5 ± 12.6 years) who received all-in-one PN, including amino acids, glucose, and lipids supplemented with pure fish oil ILE, was performed. Pure fish oil ILE (Omegaven®, Fresenius Kabi, Bad Homburg, Germany) was used along with the standard ILE to reach a fish oil dose of 0.4–0.5 g fish oil/kg/d. Diagnoses were chronic intestinal failure (CIF, n = 20), Crohn’s disease (CD, n = 22), and ulcerative colitis (UC, n = 19). The observation period was 12 months for CIF and 21 days for UC and CD. Results: A reduction in inflammation was noticeable in all patients and became statistically significant in CD (hsCRP p < 0.0001, ESR p = 0.0034, procalcitonin p = 0.0014, Il-6 p = 0.001) and UC groups (hsCRP and ESR p < 0.0001, Il-6 p = 0.0001, TNF-α p = 0.0113). In the CIF group, the total bilirubin concentration (p = 0.2157) and aspartate transaminase SGOT (p = 0.1785) did not vary over time. Conclusions: PN with pure fish oil ILE reduces some inflammatory parameters in IBD and maintains liver function parameters in CIF patients. Fish oil might become a valuable ingredient in both short- and long-term PN in patients at risk of liver dysfunction. |
format | Online Article Text |
id | pubmed-7551918 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75519182020-10-14 High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers Klek, Stanislaw Mankowska-Wierzbicka, Dorota Scislo, Lucyna Walewska, Elzbieta Pietka, Magdalena Szczepanek, Kinga Nutrients Article Aim: Patients on parenteral nutrition (PN) are prone to inflammation. This may aggravate an existing proinflammatory state and become a critical factor in the development of liver dysfunction (LD). Intravenous fish oil may attenuate this inflammatory state, but data on its use in adults are scarce. The aim of this study was to investigate the effects of adding a pure fish oil intravenous lipid emulsion (ILE) into short- and long-term PN in patients either at risk of, or with existing, inflammation. Methods: A retrospective analysis of 61 patients (32 female, 29 male, mean age 51.5 ± 12.6 years) who received all-in-one PN, including amino acids, glucose, and lipids supplemented with pure fish oil ILE, was performed. Pure fish oil ILE (Omegaven®, Fresenius Kabi, Bad Homburg, Germany) was used along with the standard ILE to reach a fish oil dose of 0.4–0.5 g fish oil/kg/d. Diagnoses were chronic intestinal failure (CIF, n = 20), Crohn’s disease (CD, n = 22), and ulcerative colitis (UC, n = 19). The observation period was 12 months for CIF and 21 days for UC and CD. Results: A reduction in inflammation was noticeable in all patients and became statistically significant in CD (hsCRP p < 0.0001, ESR p = 0.0034, procalcitonin p = 0.0014, Il-6 p = 0.001) and UC groups (hsCRP and ESR p < 0.0001, Il-6 p = 0.0001, TNF-α p = 0.0113). In the CIF group, the total bilirubin concentration (p = 0.2157) and aspartate transaminase SGOT (p = 0.1785) did not vary over time. Conclusions: PN with pure fish oil ILE reduces some inflammatory parameters in IBD and maintains liver function parameters in CIF patients. Fish oil might become a valuable ingredient in both short- and long-term PN in patients at risk of liver dysfunction. MDPI 2020-09-19 /pmc/articles/PMC7551918/ /pubmed/32961695 http://dx.doi.org/10.3390/nu12092865 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Klek, Stanislaw Mankowska-Wierzbicka, Dorota Scislo, Lucyna Walewska, Elzbieta Pietka, Magdalena Szczepanek, Kinga High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers |
title | High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers |
title_full | High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers |
title_fullStr | High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers |
title_full_unstemmed | High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers |
title_short | High Dose Intravenous Fish Oil Reduces Inflammation—A Retrospective Tale from Two Centers |
title_sort | high dose intravenous fish oil reduces inflammation—a retrospective tale from two centers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551918/ https://www.ncbi.nlm.nih.gov/pubmed/32961695 http://dx.doi.org/10.3390/nu12092865 |
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