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Vitamin K and Kidney Transplantation

The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is cur...

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Autores principales: Fusaro, Maria, Cosmai, Laura, Evenepoel, Pieter, Nickolas, Thomas L., Cheung, Angela M., Aghi, Andrea, Tripepi, Giovanni, Plebani, Mario, Iervasi, Giorgio, Vettor, Roberto, Zaninotto, Martina, Ravera, Maura, Foramitti, Marina, Giannini, Sandro, Sella, Stefania, Gallieni, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551925/
https://www.ncbi.nlm.nih.gov/pubmed/32899501
http://dx.doi.org/10.3390/nu12092717
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author Fusaro, Maria
Cosmai, Laura
Evenepoel, Pieter
Nickolas, Thomas L.
Cheung, Angela M.
Aghi, Andrea
Tripepi, Giovanni
Plebani, Mario
Iervasi, Giorgio
Vettor, Roberto
Zaninotto, Martina
Ravera, Maura
Foramitti, Marina
Giannini, Sandro
Sella, Stefania
Gallieni, Maurizio
author_facet Fusaro, Maria
Cosmai, Laura
Evenepoel, Pieter
Nickolas, Thomas L.
Cheung, Angela M.
Aghi, Andrea
Tripepi, Giovanni
Plebani, Mario
Iervasi, Giorgio
Vettor, Roberto
Zaninotto, Martina
Ravera, Maura
Foramitti, Marina
Giannini, Sandro
Sella, Stefania
Gallieni, Maurizio
author_sort Fusaro, Maria
collection PubMed
description The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches.
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spelling pubmed-75519252020-10-14 Vitamin K and Kidney Transplantation Fusaro, Maria Cosmai, Laura Evenepoel, Pieter Nickolas, Thomas L. Cheung, Angela M. Aghi, Andrea Tripepi, Giovanni Plebani, Mario Iervasi, Giorgio Vettor, Roberto Zaninotto, Martina Ravera, Maura Foramitti, Marina Giannini, Sandro Sella, Stefania Gallieni, Maurizio Nutrients Review The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches. MDPI 2020-09-05 /pmc/articles/PMC7551925/ /pubmed/32899501 http://dx.doi.org/10.3390/nu12092717 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fusaro, Maria
Cosmai, Laura
Evenepoel, Pieter
Nickolas, Thomas L.
Cheung, Angela M.
Aghi, Andrea
Tripepi, Giovanni
Plebani, Mario
Iervasi, Giorgio
Vettor, Roberto
Zaninotto, Martina
Ravera, Maura
Foramitti, Marina
Giannini, Sandro
Sella, Stefania
Gallieni, Maurizio
Vitamin K and Kidney Transplantation
title Vitamin K and Kidney Transplantation
title_full Vitamin K and Kidney Transplantation
title_fullStr Vitamin K and Kidney Transplantation
title_full_unstemmed Vitamin K and Kidney Transplantation
title_short Vitamin K and Kidney Transplantation
title_sort vitamin k and kidney transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551925/
https://www.ncbi.nlm.nih.gov/pubmed/32899501
http://dx.doi.org/10.3390/nu12092717
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