Cargando…
Vitamin K and Kidney Transplantation
The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is cur...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551925/ https://www.ncbi.nlm.nih.gov/pubmed/32899501 http://dx.doi.org/10.3390/nu12092717 |
_version_ | 1783593287499644928 |
---|---|
author | Fusaro, Maria Cosmai, Laura Evenepoel, Pieter Nickolas, Thomas L. Cheung, Angela M. Aghi, Andrea Tripepi, Giovanni Plebani, Mario Iervasi, Giorgio Vettor, Roberto Zaninotto, Martina Ravera, Maura Foramitti, Marina Giannini, Sandro Sella, Stefania Gallieni, Maurizio |
author_facet | Fusaro, Maria Cosmai, Laura Evenepoel, Pieter Nickolas, Thomas L. Cheung, Angela M. Aghi, Andrea Tripepi, Giovanni Plebani, Mario Iervasi, Giorgio Vettor, Roberto Zaninotto, Martina Ravera, Maura Foramitti, Marina Giannini, Sandro Sella, Stefania Gallieni, Maurizio |
author_sort | Fusaro, Maria |
collection | PubMed |
description | The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches. |
format | Online Article Text |
id | pubmed-7551925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75519252020-10-14 Vitamin K and Kidney Transplantation Fusaro, Maria Cosmai, Laura Evenepoel, Pieter Nickolas, Thomas L. Cheung, Angela M. Aghi, Andrea Tripepi, Giovanni Plebani, Mario Iervasi, Giorgio Vettor, Roberto Zaninotto, Martina Ravera, Maura Foramitti, Marina Giannini, Sandro Sella, Stefania Gallieni, Maurizio Nutrients Review The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches. MDPI 2020-09-05 /pmc/articles/PMC7551925/ /pubmed/32899501 http://dx.doi.org/10.3390/nu12092717 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fusaro, Maria Cosmai, Laura Evenepoel, Pieter Nickolas, Thomas L. Cheung, Angela M. Aghi, Andrea Tripepi, Giovanni Plebani, Mario Iervasi, Giorgio Vettor, Roberto Zaninotto, Martina Ravera, Maura Foramitti, Marina Giannini, Sandro Sella, Stefania Gallieni, Maurizio Vitamin K and Kidney Transplantation |
title | Vitamin K and Kidney Transplantation |
title_full | Vitamin K and Kidney Transplantation |
title_fullStr | Vitamin K and Kidney Transplantation |
title_full_unstemmed | Vitamin K and Kidney Transplantation |
title_short | Vitamin K and Kidney Transplantation |
title_sort | vitamin k and kidney transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551925/ https://www.ncbi.nlm.nih.gov/pubmed/32899501 http://dx.doi.org/10.3390/nu12092717 |
work_keys_str_mv | AT fusaromaria vitaminkandkidneytransplantation AT cosmailaura vitaminkandkidneytransplantation AT evenepoelpieter vitaminkandkidneytransplantation AT nickolasthomasl vitaminkandkidneytransplantation AT cheungangelam vitaminkandkidneytransplantation AT aghiandrea vitaminkandkidneytransplantation AT tripepigiovanni vitaminkandkidneytransplantation AT plebanimario vitaminkandkidneytransplantation AT iervasigiorgio vitaminkandkidneytransplantation AT vettorroberto vitaminkandkidneytransplantation AT zaninottomartina vitaminkandkidneytransplantation AT raveramaura vitaminkandkidneytransplantation AT foramittimarina vitaminkandkidneytransplantation AT gianninisandro vitaminkandkidneytransplantation AT sellastefania vitaminkandkidneytransplantation AT gallienimaurizio vitaminkandkidneytransplantation |