Cargando…
Progress in the Development of Universal Influenza Vaccines
Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551969/ https://www.ncbi.nlm.nih.gov/pubmed/32957468 http://dx.doi.org/10.3390/v12091033 |
_version_ | 1783593297773592576 |
---|---|
author | Sun, Wenqiang Luo, Tingrong Liu, Wenjun Li, Jing |
author_facet | Sun, Wenqiang Luo, Tingrong Liu, Wenjun Li, Jing |
author_sort | Sun, Wenqiang |
collection | PubMed |
description | Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—all of which lead to poor outcomes of routine vaccination against targeted strain subtypes. Therefore, the development of universal influenza vaccines still constitutes the ideal strategy for controlling influenza. This article reviews the progress in development of universal vaccines directed against the conserved regions of hemagglutinin (HA), neuraminidase (NA), and other structural proteins of influenza viruses using new technologies and strategies with the goals of enhancing our understanding of universal influenza vaccines and providing a reference for research into the exploitation of natural immunity against influenza viruses. |
format | Online Article Text |
id | pubmed-7551969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75519692020-10-14 Progress in the Development of Universal Influenza Vaccines Sun, Wenqiang Luo, Tingrong Liu, Wenjun Li, Jing Viruses Review Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—all of which lead to poor outcomes of routine vaccination against targeted strain subtypes. Therefore, the development of universal influenza vaccines still constitutes the ideal strategy for controlling influenza. This article reviews the progress in development of universal vaccines directed against the conserved regions of hemagglutinin (HA), neuraminidase (NA), and other structural proteins of influenza viruses using new technologies and strategies with the goals of enhancing our understanding of universal influenza vaccines and providing a reference for research into the exploitation of natural immunity against influenza viruses. MDPI 2020-09-17 /pmc/articles/PMC7551969/ /pubmed/32957468 http://dx.doi.org/10.3390/v12091033 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sun, Wenqiang Luo, Tingrong Liu, Wenjun Li, Jing Progress in the Development of Universal Influenza Vaccines |
title | Progress in the Development of Universal Influenza Vaccines |
title_full | Progress in the Development of Universal Influenza Vaccines |
title_fullStr | Progress in the Development of Universal Influenza Vaccines |
title_full_unstemmed | Progress in the Development of Universal Influenza Vaccines |
title_short | Progress in the Development of Universal Influenza Vaccines |
title_sort | progress in the development of universal influenza vaccines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551969/ https://www.ncbi.nlm.nih.gov/pubmed/32957468 http://dx.doi.org/10.3390/v12091033 |
work_keys_str_mv | AT sunwenqiang progressinthedevelopmentofuniversalinfluenzavaccines AT luotingrong progressinthedevelopmentofuniversalinfluenzavaccines AT liuwenjun progressinthedevelopmentofuniversalinfluenzavaccines AT lijing progressinthedevelopmentofuniversalinfluenzavaccines |