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Progress in the Development of Universal Influenza Vaccines

Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—...

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Detalles Bibliográficos
Autores principales: Sun, Wenqiang, Luo, Tingrong, Liu, Wenjun, Li, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551969/
https://www.ncbi.nlm.nih.gov/pubmed/32957468
http://dx.doi.org/10.3390/v12091033
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author Sun, Wenqiang
Luo, Tingrong
Liu, Wenjun
Li, Jing
author_facet Sun, Wenqiang
Luo, Tingrong
Liu, Wenjun
Li, Jing
author_sort Sun, Wenqiang
collection PubMed
description Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—all of which lead to poor outcomes of routine vaccination against targeted strain subtypes. Therefore, the development of universal influenza vaccines still constitutes the ideal strategy for controlling influenza. This article reviews the progress in development of universal vaccines directed against the conserved regions of hemagglutinin (HA), neuraminidase (NA), and other structural proteins of influenza viruses using new technologies and strategies with the goals of enhancing our understanding of universal influenza vaccines and providing a reference for research into the exploitation of natural immunity against influenza viruses.
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spelling pubmed-75519692020-10-14 Progress in the Development of Universal Influenza Vaccines Sun, Wenqiang Luo, Tingrong Liu, Wenjun Li, Jing Viruses Review Influenza viruses pose a significant threat to human health. They are responsible for a large number of deaths annually and have a serious impact on the global economy. There are numerous influenza virus subtypes, antigenic variations occur continuously, and epidemic trends are difficult to predict—all of which lead to poor outcomes of routine vaccination against targeted strain subtypes. Therefore, the development of universal influenza vaccines still constitutes the ideal strategy for controlling influenza. This article reviews the progress in development of universal vaccines directed against the conserved regions of hemagglutinin (HA), neuraminidase (NA), and other structural proteins of influenza viruses using new technologies and strategies with the goals of enhancing our understanding of universal influenza vaccines and providing a reference for research into the exploitation of natural immunity against influenza viruses. MDPI 2020-09-17 /pmc/articles/PMC7551969/ /pubmed/32957468 http://dx.doi.org/10.3390/v12091033 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Wenqiang
Luo, Tingrong
Liu, Wenjun
Li, Jing
Progress in the Development of Universal Influenza Vaccines
title Progress in the Development of Universal Influenza Vaccines
title_full Progress in the Development of Universal Influenza Vaccines
title_fullStr Progress in the Development of Universal Influenza Vaccines
title_full_unstemmed Progress in the Development of Universal Influenza Vaccines
title_short Progress in the Development of Universal Influenza Vaccines
title_sort progress in the development of universal influenza vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551969/
https://www.ncbi.nlm.nih.gov/pubmed/32957468
http://dx.doi.org/10.3390/v12091033
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