Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice

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An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence i...

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Detalles Bibliográficos
Autores principales: Loes, Andrea N., Gentles, Lauren E., Greaney, Allison J., Crawford, Katharine H. D., Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552029/
https://www.ncbi.nlm.nih.gov/pubmed/32899480
http://dx.doi.org/10.3390/v12090987
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