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En Guard! The Interactions between Adenoviruses and the DNA Damage Response
Virus–host cell interactions include several skirmishes between the virus and its host, and the DNA damage response (DDR) network is one of their important battlegrounds. Although some aspects of the DDR are exploited by adenovirus (Ad) to improve virus replication, especially at the early phase of...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552057/ https://www.ncbi.nlm.nih.gov/pubmed/32906746 http://dx.doi.org/10.3390/v12090996 |
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author | Kleinberger, Tamar |
author_facet | Kleinberger, Tamar |
author_sort | Kleinberger, Tamar |
collection | PubMed |
description | Virus–host cell interactions include several skirmishes between the virus and its host, and the DNA damage response (DDR) network is one of their important battlegrounds. Although some aspects of the DDR are exploited by adenovirus (Ad) to improve virus replication, especially at the early phase of infection, a large body of evidence demonstrates that Ad devotes many of its proteins, including E1B-55K, E4orf3, E4orf4, E4orf6, and core protein VII, and utilizes varied mechanisms to inhibit the DDR. These findings indicate that the DDR would strongly restrict Ad replication if allowed to function efficiently. Various Ad serotypes inactivate DNA damage sensors, including the Mre11-Rad50-Nbs1 (MRN) complex, DNA-dependent protein kinase (DNA-PK), and Poly (ADP-ribose) polymerase 1 (PARP-1). As a result, these viruses inhibit signaling via DDR transducers, such as the ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases, to downstream effectors. The different Ad serotypes utilize both shared and distinct mechanisms to inhibit various branches of the DDR. The aim of this review is to understand the interactions between Ad proteins and the DDR and to appreciate how these interactions contribute to viral replication. |
format | Online Article Text |
id | pubmed-7552057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75520572020-10-14 En Guard! The Interactions between Adenoviruses and the DNA Damage Response Kleinberger, Tamar Viruses Review Virus–host cell interactions include several skirmishes between the virus and its host, and the DNA damage response (DDR) network is one of their important battlegrounds. Although some aspects of the DDR are exploited by adenovirus (Ad) to improve virus replication, especially at the early phase of infection, a large body of evidence demonstrates that Ad devotes many of its proteins, including E1B-55K, E4orf3, E4orf4, E4orf6, and core protein VII, and utilizes varied mechanisms to inhibit the DDR. These findings indicate that the DDR would strongly restrict Ad replication if allowed to function efficiently. Various Ad serotypes inactivate DNA damage sensors, including the Mre11-Rad50-Nbs1 (MRN) complex, DNA-dependent protein kinase (DNA-PK), and Poly (ADP-ribose) polymerase 1 (PARP-1). As a result, these viruses inhibit signaling via DDR transducers, such as the ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases, to downstream effectors. The different Ad serotypes utilize both shared and distinct mechanisms to inhibit various branches of the DDR. The aim of this review is to understand the interactions between Ad proteins and the DDR and to appreciate how these interactions contribute to viral replication. MDPI 2020-09-07 /pmc/articles/PMC7552057/ /pubmed/32906746 http://dx.doi.org/10.3390/v12090996 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kleinberger, Tamar En Guard! The Interactions between Adenoviruses and the DNA Damage Response |
title | En Guard! The Interactions between Adenoviruses and the DNA Damage Response |
title_full | En Guard! The Interactions between Adenoviruses and the DNA Damage Response |
title_fullStr | En Guard! The Interactions between Adenoviruses and the DNA Damage Response |
title_full_unstemmed | En Guard! The Interactions between Adenoviruses and the DNA Damage Response |
title_short | En Guard! The Interactions between Adenoviruses and the DNA Damage Response |
title_sort | en guard! the interactions between adenoviruses and the dna damage response |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552057/ https://www.ncbi.nlm.nih.gov/pubmed/32906746 http://dx.doi.org/10.3390/v12090996 |
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